Results 91 to 100 of about 19,134 (215)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm

Frontiers in Cell and Developmental Biology, 2020
Mammalian oocytes are enveloped by the zona pellucida (ZP), an extracellular matrix of glycoproteins. In sperm, stimulation with ZP proteins evokes a rapid Ca2+ influx via the sperm-specific, pH-sensitive Ca2+ channel CatSper.
Melanie Balbach, Hussein Hamzeh, Jan F. Jikeli, Christoph Brenker, Christian Schiffer, Jan N. Hansen, Pia Neugebauer, Christian Trötschel, Luca Jovine, Ling Han, Harvey M. Florman, U. Benjamin Kaupp, U. Benjamin Kaupp, Timo Strünker, Dagmar Wachten   +14 more
doaj   +1 more source

Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells. [PDF]

PLoS ONE, 2014
Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that subverts cellular signaling by ...
Irena Adkins, Jana Kamanova, Aneta Kocourkova, Martina Svedova, Jakub Tomala, Hana Janova, Jiri Masin, Barbora Chladkova, Ladislav Bumba, Marek Kovar, Padraig J Ross, Ludmila Tuckova, Radek Spisek, Kingston H G Mills, Peter Sebo   +14 more
doaj   +1 more source

Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe [PDF]

, 1992
We have identified, cloned, and studied a gene, cap, encoding a protein that is associated with adenylyl cyclase in the fission yeast Schizosaccharomyces pombe.
Field, J., Gerst, J., Kawamukai, M., Riggs, M., Rodgers, L., Wigler, M. H., Young, D.   +6 more
core   +2 more sources

Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction [PDF]

Biochemical and Biophysical Research Communications, 2007
cAMP is important in sea urchin sperm signaling, yet the molecular nature of the adenylyl cyclases (ACs) involved remained unknown. These cells were recently shown to contain an ortholog of the mammalian soluble adenylyl cyclase (sAC). Here, we show that sAC is present in the sperm head and as in mammals is stimulated by bicarbonate.
Carmen, Beltrán, Victor D, Vacquier, Gary, Moy, Yanqiu, Chen, Jochen, Buck, Lonny R, Levin, Alberto, Darszon   +6 more
openaire   +2 more sources

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, EarlyView.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Physiological Sensing of Carbon Dioxide/Bicarbonate/pH via Cyclic Nucleotide Signaling

Sensors, 2011
Carbon dioxide (CO2) is produced by living organisms as a byproduct of metabolism. In physiological systems, CO2 is unequivocally linked with bicarbonate (HCO3−) and pH via a ubiquitous family of carbonic anhydrases, and numerous biological processes are
Lonny R. Levin, Jochen Buck
doaj   +1 more source

Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. [PDF]

, 2013
Fertilization competence is acquired in the female tract in a process known as capacitation. Capacitation is needed for the activation of motility (e.g. hyperactivation) and to prepare the sperm for an exocytotic process known as acrosome reaction. While
Buck, Jochen, Darszon, Alberto, de la Vega Beltran, José L., Escoffier, Jessica, Haddad, Douglas, Krapf, Dario, Levin, Lonny R., Mager, Jesse, Navarrete, Felipe, Salicioni, Ana M., Sánchez Cárdenas, Claudia, Visconti, Pablo E., Wertheimer Hermitte, Eva Victoria   +12 more
core   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, EarlyView.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

An adenylyl cyclase like-9 gene (NlAC9) influences growth and fecundity in the brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae). [PDF]

PLoS ONE, 2017
The cAMP/PKA intracellular signaling pathway is launched by adenylyl cyclase (AC) conversion of adenosine triphosphate (ATP) to 3', 5'-cyclic AMP (cAMP) and cAMP-dependent activation of PKA.
LinQuan Ge, HaoTian Gu, Bo Huang, Qisheng Song, David Stanley, Fang Liu, Guo-Qing Yang, Jin-Cai Wu   +7 more
doaj   +1 more source