Results 101 to 110 of about 19,255 (216)

Bicarbonate-regulated soluble adenylyl cyclase.

JOP : Journal of the pancreas, 2002
Soluble adenylyl cyclase (sAC) represents a novel form of mammalian adenylyl cyclase structurally, molecularly, and biochemically distinct from the G protein-regulated, transmembrane adenylyl cyclases (tmACs). sAC possesses no transmembrane domains and is insensitive to classic modulators of tmACs, such as heterotrimeric G proteins and P site ligands ...
M S, Wuttke, J, Buck, L R, Levin
openaire   +1 more source

Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors [PDF]

Respiratory Physiology & Neurobiology, 2013
Stimulation of the carotid body (CB) chemoreceptors by hypercapnia triggers a reflex ventilatory response via a cascade of cellular events, which includes generation of cAMP. However, it is not known if molecular CO2/HCO3(-) and/or H(+) mediate this effect and how these molecules contribute to cAMP production.
Ana R, Nunes, Andrew P S, Holmes, Vedangi, Sample, Prem, Kumar, Martin J, Cann, Emília C, Monteiro, Jin, Zhang, Estelle B, Gauda   +7 more
openaire   +2 more sources

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference! [PDF]

, 2015
Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the most serious human diseases, including Chagas disease (Trypanosoma ...
De Koning, Harry P., Kalejaiye, Titilola D., Tagoe, Daniel N. A.   +2 more
core   +1 more source

Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain [PDF]

The Journal of Cell Biology, 2004
Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular
Zippin, Jonathan H., Farrell, Jeanne, Huron, David, Kamenetsky, Margarita, Hess, Kenneth C., Fischman, Donald A., Levin, Lonny R., Buck, Jochen   +7 more
openaire   +2 more sources

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity

Cell Death and Disease, 2021
Cyclic adenosine monophosphate (cAMP) is a master regulator of mitochondrial metabolism but its precise mechanism of action yet remains unclear. Here, we found that a dietary saturated fatty acid (FA), palmitate increased intracellular cAMP synthesis ...
Marion Laudette, Yannis Sainte-Marie, Grégoire Cousin, Dorian Bergonnier, Ismahane Belhabib, Stéphanie Brun, Karina Formoso, Loubna Laib, Florence Tortosa, Camille Bergoglio, Bertrand Marcheix, Jan Borén, Olivier Lairez, Jérémy Fauconnier, Alexandre Lucas, Jeanne Mialet-Perez, Cédric Moro, Frank Lezoualc’h   +17 more
doaj   +1 more source

Characterization of soluble forms of nonchimeric type V adenylyl cyclases [PDF]

Proceedings of the National Academy of Sciences, 1997
Type V adenylyl cyclase (ACV) belongs to the family of Ca 2+ - inhibited cyclases. We have generated two soluble forms of the enzyme containing the C1 or C1a region (which lacks the C-terminal 112 amino acids) linked to the C2 domain and compared their regulation with the full-length ACV. All three forms of ACV were
K, Scholich, A J, Barbier, J B, Mullenix, T B, Patel   +3 more
openaire   +2 more sources

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, Volume 13, Issue 5, 27 January 2026.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION [PDF]

, 2018
Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction
Baldwin, Tanya A., Baldwin, Tanya A.
core   +1 more source