Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. [PDF]
, 2019 Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known.
Ahn, Sangphil +6 more
core +1 more source
Proton Fall or Bicarbonate Rise: Glycolytic Rate In Mouse Astrocytes Is Paved By Intracellular Alkalinization [PDF]
, 2016 Glycolysis is the primary step for major energy production in the cell. There is strong evidence suggesting that glucose consumption and rate of glycolysis are highly modulated by cytosolic pH/[H(+)], but those can also be stimulated by an increase in ...
Deitmer, JW +4 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
P2 Calcium Induced Intramitochondrial cAMP Signalling Enhances Aldosterone Secretion
Artery Research, 2020 Elevation of plasma [K+] and [angiotensin II] (Ang II), two major physiological stimuli of adrenal zona glomerulosa cells, increase aldosterone production by triggering cytosolic Ca2+ signalling.
Gergő Szanda +3 more
doaj +1 more source
Bicarbonate is required for migration of sperm epididymal protein DE/CRISP-1 to the equatorial segment and expression of rat sperm fusion ability [PDF]
, 2004 Numerous studies have demonstrated that sperm capacitation is a bicarbonate-dependent process. In the rat, capacitation has not been studied as much as in other species, mainly because of the difficulties in carrying out functional assays with this ...
Busso, Dolores +6 more
core +1 more source
Journal of Pharmacological Sciences, 2011 .: To investigate the effect of hypoxia or hypoxia/reoxygenation on vascular smooth muscle function, mechanical response of monkey coronary artery without endothelium was studied under normoxia, hypoxia, and hypoxia/reoxygenation.
Masashi Tawa +6 more
doaj +1 more source
Role of soluble adenylyl cyclase in cell death and growth
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 cAMP signaling is an evolutionarily conserved intracellular communication system controlling numerous cellular functions. Until recently, transmembrane adenylyl cyclase (tmAC) was considered the major source for cAMP in the cell, and the role of cAMP signaling was therefore attributed exclusively to the activity of this family of enzymes.
Ladilov, Yury, Appukuttan, Avinash
openaire +2 more sources
Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling.
PLoS ONEHippocampal neurons exhibit activation of both the conventional transmembrane adenylyl cyclases (tmACs) and the non-canonical soluble adenylyl cyclase (sAC) as sources of cyclic AMP (cAMP). These two cAMP sources play crucial roles in mediating signaling
Natalia G Armando +4 more
doaj +1 more source
Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility [PDF]
, 2011 Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg.
Aghajanian, Haig K. +5 more
core +1 more source
Soluble adenylyl cyclase mediates bicarbonate-dependent corneal endothelial cell protection
American Journal of Physiology-Cell Physiology, 2011 Cyclic AMP produced from membrane receptor complex bound adenylyl cyclases is protective in corneal endothelial cells (CEC). CEC also express soluble adenylyl cyclase (sAC), which is localized throughout the cytoplasm. When activated by HCO3−, cAMP concentration ([cAMP]) increases by ∼50%. Here we ask if cAMP produced from sAC is also protective.
Shimin, Li +2 more
openaire +3 more sources