Results 121 to 130 of about 19,134 (215)
Regulation of bicarbonate secretion in marine fish intestine by the calcium-sensing receptor [PDF]
, 2018 In marine fish, high epithelial intestinal HCO3- secretion generates luminal carbonate precipitates of divalent cations that play a key role in water and ion homeostasis.
Fuentes, Juan, Gregorio, Silvia
core +2 more sources
Phosphodiesterase Inhibition Increases Striatal GDNF and Protects Against Preclinical Parkinsonism
Journal of Neurochemistry, Volume 169, Issue 12, December 2025.Parkinson's disease (PD) involves the progressive death of dopamine‐secreting neurons. This research investigates the neuroprotective role of the pharmacological inhibition of phosphodiesterases (PDE) by Ibudilast. This drug elevates levels of the signaling molecule cAMP, which boosts the production of GDNF, a potent neuroprotective factor naturally ...
Xavier d’Anglemont de Tassigny +3 more
wiley +1 more source
Cyclic nucleotide signalling in malaria parasites. [PDF]
, 2017 The cyclic nucleotides 3', 5'-cyclic adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types.
Baker, David A +6 more
core +1 more source
Journal of Neurochemistry, Volume 169, Issue 12, December 2025.We examined how cannabinoid receptor activation shapes astrocytic energy metabolism and membrane dynamics. Live‐cell Förster resonance energy transfer (FRET) microscopy showed that stimulation with the CB1‐selective agonist ACEA or the CB2‐biased ligands AM1241 and Gp1a increased intracellular D‐glucose ([D‐glucose]ᵢ) and L‐lactate ([L‐lactate]ᵢ) in ...
Katja Fink, Robert Zorec, Marko Kreft
wiley +1 more source
The Beta-1-Receptor Blocker Nebivolol Elicits Dilation of Cerebral Arteries by Reducing Smooth Muscle [Ca2+]i [PDF]
, 2018 K
Cséplő, Péter +5 more
core +1 more source
Plant, Cell &Environment, Volume 48, Issue 12, Page 8561-8572, December 2025.ABSTRACT Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore assays, this study aimed at providing a holistic description of maize root responses to EPNs and to assess ...
Arletys M. Verdecia‐Mogena +7 more
wiley +1 more source
Bicarbonate is required for migration of sperm epididymal protein DE/CRISP-1 to the equatorial segment and expression of rat sperm fusion ability [PDF]
, 2004 Numerous studies have demonstrated that sperm capacitation is a bicarbonate-dependent process. In the rat, capacitation has not been studied as much as in other species, mainly because of the difficulties in carrying out functional assays with this ...
Busso, Dolores +6 more
core +1 more source
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, Volume 599, Issue 22, Page 3381-3391, November 2025.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
Ciliary adenylyl cyclases control the Hedgehog pathway [PDF]
, 2015 Protein kinase A (PKA) accumulates at the base of the cilium where it negatively regulates the Hedgehog (Hh) pathway. Although PKA activity is essentially controlled by the cAMP produced by adenylyl cyclases, the influence of these enzymes on the Hh ...
Herrera, Antonio +4 more
core +1 more source
Journal of Pharmacological Sciences, 2011 .: To investigate the effect of hypoxia or hypoxia/reoxygenation on vascular smooth muscle function, mechanical response of monkey coronary artery without endothelium was studied under normoxia, hypoxia, and hypoxia/reoxygenation.
Masashi Tawa +6 more
doaj +1 more source