The Spatiotemporal Regulation of cAMP Signaling in Blood Platelets—Old Friends and New Players [PDF]
, 2015 Atherothrombosis, the pathology underlying numerous cardiovascular diseases, is a major cause of death globally. Hyperactive blood platelets play a key role in the atherothrombotic process through the release of inflammatory mediators and formation of ...
Aburima +45 more
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Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling.
PLoS ONEHippocampal neurons exhibit activation of both the conventional transmembrane adenylyl cyclases (tmACs) and the non-canonical soluble adenylyl cyclase (sAC) as sources of cyclic AMP (cAMP). These two cAMP sources play crucial roles in mediating signaling
Natalia G Armando +4 more
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Soluble adenylyl cyclase, the cell-autonomous member of the family
Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseSoluble adenylyl cyclase (sAC) is the evolutionarily most ancient of a set of 10 adenylyl cyclases (Adcys). While Adcy1 to Adcy9 are cAMP-producing enzymes that are activated by G-protein coupled receptors (GPCRs), Adcy10 (sAC) is an intracellular adenylyl cyclase.
Hang Lam, Li +4 more
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Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility [PDF]
, 2011 Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg.
Aghajanian, Haig K. +5 more
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A Soluble C1b Protein and Its Regulation of Soluble Type 7 Adenylyl Cyclase
Biochemistry, 2004 Adenylyl cyclase (AC) is a prototypical cell-signaling molecule expressed in virtually all organisms from bacteria to man. While C1b, a poorly conserved region within mammalian AC, has been implicated in numerous isoform-specific regulatory properties, no one has purified the C1b region as a functional protein to homogeneity in order to study its role ...
Jeff A, Beeler +5 more
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Roles of lipid raft in the regulation of sperm motility in the ascidian Ciona intestinalis [PDF]
, 2011 Thesis (Ph. D. in Science)--University of Tsukuba, (A), no. 5938, 2011.11.30Includes bibliographical references (p.
朱 麗紅
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Soluble Adenylyl Cyclase Activity Is Necessary for Retinal Ganglion Cell Survival and Axon Growth [PDF]
, 2012 Raul G. Corredor +5 more
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Bicarbonate-regulated soluble adenylyl cyclase.
JOP : Journal of the pancreas, 2002 Soluble adenylyl cyclase (sAC) represents a novel form of mammalian adenylyl cyclase structurally, molecularly, and biochemically distinct from the G protein-regulated, transmembrane adenylyl cyclases (tmACs). sAC possesses no transmembrane domains and is insensitive to classic modulators of tmACs, such as heterotrimeric G proteins and P site ligands ...
M S, Wuttke, J, Buck, L R, Levin
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Editorial: Advances in cAMP signaling research: basic and translational aspects
Frontiers in Physiology, 2023 Muhammad Aslam +3 more
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Nitric oxide enhances de novo formation of endothelial gap junctions [PDF]
, 2003 Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in this tissue.
Gloe, Torsten +3 more
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