Results 201 to 210 of about 19,255 (216)

Lactate modulates iron metabolism by binding soluble adenylyl cyclase

Cell Metabolism, 2023
Overproduction of lactate (LA) can occur during exercise and in many diseases such as cancers. Individuals with hyperlactatemia often display anemia, decreased serum iron, and elevated hepcidin, a key regulator of iron metabolism. However, it is unknown whether and how LA regulates hepcidin expression. Here, we show LA binds to soluble adenylyl cyclase
Wei, Liu, Shuping, Zhang, Quanjin, Li, Yue, Wu, Xuan, Jia, Wenya, Feng, Zhaolong, Li, Yali, Shi, Qingzhi, Hou, Juan, Ma, Yajun, Liu, Pu, Gao, Tomas, Ganz, Sijin, Liu   +13 more
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Purification of Soluble Adenylyl Cyclase

2002
Cyclic AMP (cAMP), the nearly universal second messenger, is synthesized by a broad family of adenylyl cyclases (ACs). Mammals have at least nine isoforms of transmembrane-spanning adenylyl cyclases (tmACs). These differ in their expression patterns, and their catalytic activities are differentially regulated by G proteins and other signaling molecules.
Jochen, Buck, Meeghan L, Sinclair, Lonny R, Levin   +2 more
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Expression of soluble adenylyl cyclase in acral melanomas

Clinical and Experimental Dermatology, 2015
Soluble adenylyl cyclase (sAC) regulates melanocytic cells, and is a diagnostic marker for pigmented skin lesions. Because only a few studies on sAC expression in acral melanomas have been performed, we investigated the histopathological significance of sAC expression in 33 cases of acral melanoma, and assessed its diagnostic value in distinguishing ...
H, Li, S M, Kim, V, Savkovic, S A, Jin, Y D, Choi, S J, Yun   +5 more
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A soluble adenylyl cyclase from sea urchin spermatozoa

Gene, 2005
A previously identified, calmodulin-binding, sea urchin sperm flagellar adenylyl cyclase (AC) was cloned and sequenced and found to be a homologue of mammalian sperm soluble adenylyl cyclase (sAC). Compared to the mammalian sAC, the sea urchin sAC (susAC) has several long amino acid insertions, some of which contain protein kinase A phosphorylation ...
Mamoru, Nomura, Carmen, Beltrán, Alberto, Darszon, Victor D, Vacquier   +3 more
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Construction of Soluble Adenylyl Cyclase from Human Membrane-Bound Type 7 Adenylyl Cyclase

2002
Adenylyl cyclase is the sole enzyme to synthesize cyclic AMP (cAMP), a key, second messenger that regulates diverse physiological responses including sugar and lipid metabolism, olfaction, and cell growth and differentiation. Most adenylyl cyclase activity in mammalian tissues is found in plasma membrane preparations with the exception of the ...
Shui-Zhong, Yan, Wei-Jen, Tang
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Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor

Science, 2000
Spermatozoa undergo a poorly understood activation process induced by bicarbonate and mediated by cyclic adenosine 3′,5′-monophosphate (cAMP). It has been assumed that bicarbonate mediates its effects through changes in intracellular pH or membrane potential; however, we demonstrate here that bicarbonate directly stimulates mammalian soluble adenylyl ...
Y, Chen, M J, Cann, T N, Litvin, V, Iourgenko, M L, Sinclair, L R, Levin, J, Buck   +6 more
openaire   +2 more sources

Cloning and characterization of the human soluble adenylyl cyclase

American Journal of Physiology-Cell Physiology, 2005
We identified the human ortholog of soluble adenylyl cyclase (hsAC) in a locus linked to familial absorptive hypercalciuria and cloned it from a human cDNA library. hsAC transcripts were expressed in multiple tissues using RT-PCR and RNA blotting. RNA blot analysis revealed a predominant 5.1-kb band in a multiple human tissue blot, but three splice ...
Weidong, Geng, Zenglu, Wang, Jianning, Zhang, Berenice Y, Reed, Charles Y C, Pak, Orson W, Moe   +5 more
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Soluble Adenylyl Cyclase: Potential Role in Mineral Metabolism

AIP Conference Proceedings, 2007
The conversion of a signal of inorganic ion concentration to a second messenger is of fundamental biologic significance. The soluble adenylyl cyclase (sAC) serves such a purpose by transducing divalent cation concentrations and bicarbonate concentrations into intracellular cyclic AMP levels.
Weidong Geng, Orson W. Moe
openaire   +1 more source

A seminal study of soluble adenylyl cyclase

Nature Structural & Molecular Biology, 2005
In mammals, a soluble bicarbonate-regulated adenylyl cyclase is required for sperm fertility. Crystal structures of a cyanobacterial cousin provide new insights into the molecular mechanisms of activation and catalysis in soluble adenylyl cyclase and other class III nucleotidyl cyclases.
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Specific expression of soluble adenylyl cyclase in male germ cells

Molecular Reproduction and Development, 2000
The cAMP signaling pathway is an important mediator of extracellular signals in organisms from prokaryotes to higher eukaryotes. In mammals two types of adenylyl cyclase synthesize cAMP; a ubiquitous family of transmembrane isoforms regulated by G proteins in response to extracellular signals, and a recently isolated soluble enzyme insensitive to ...
M L, Sinclair, X Y, Wang, M, Mattia, M, Conti, J, Buck, D J, Wolgemuth, L R, Levin   +6 more
openaire   +2 more sources