Results 201 to 210 of about 19,134 (215)

Purification of Soluble Adenylyl Cyclase

2002
Cyclic AMP (cAMP), the nearly universal second messenger, is synthesized by a broad family of adenylyl cyclases (ACs). Mammals have at least nine isoforms of transmembrane-spanning adenylyl cyclases (tmACs). These differ in their expression patterns, and their catalytic activities are differentially regulated by G proteins and other signaling molecules.
Jochen, Buck, Meeghan L, Sinclair, Lonny R, Levin   +2 more
openaire   +2 more sources

Expression of soluble adenylyl cyclase in acral melanomas

Clinical and Experimental Dermatology, 2015
Soluble adenylyl cyclase (sAC) regulates melanocytic cells, and is a diagnostic marker for pigmented skin lesions. Because only a few studies on sAC expression in acral melanomas have been performed, we investigated the histopathological significance of sAC expression in 33 cases of acral melanoma, and assessed its diagnostic value in distinguishing ...
H, Li, S M, Kim, V, Savkovic, S A, Jin, Y D, Choi, S J, Yun   +5 more
openaire   +2 more sources

Lactate modulates iron metabolism by binding soluble adenylyl cyclase

Cell Metabolism, 2023
Overproduction of lactate (LA) can occur during exercise and in many diseases such as cancers. Individuals with hyperlactatemia often display anemia, decreased serum iron, and elevated hepcidin, a key regulator of iron metabolism. However, it is unknown whether and how LA regulates hepcidin expression. Here, we show LA binds to soluble adenylyl cyclase
Wei, Liu, Shuping, Zhang, Quanjin, Li, Yue, Wu, Xuan, Jia, Wenya, Feng, Zhaolong, Li, Yali, Shi, Qingzhi, Hou, Juan, Ma, Yajun, Liu, Pu, Gao, Tomas, Ganz, Sijin, Liu   +13 more
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Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor

Science, 2000
Spermatozoa undergo a poorly understood activation process induced by bicarbonate and mediated by cyclic adenosine 3′,5′-monophosphate (cAMP). It has been assumed that bicarbonate mediates its effects through changes in intracellular pH or membrane potential; however, we demonstrate here that bicarbonate directly stimulates mammalian soluble adenylyl ...
Y, Chen, M J, Cann, T N, Litvin, V, Iourgenko, M L, Sinclair, L R, Levin, J, Buck   +6 more
openaire   +2 more sources

Construction of Soluble Adenylyl Cyclase from Human Membrane-Bound Type 7 Adenylyl Cyclase

2002
Adenylyl cyclase is the sole enzyme to synthesize cyclic AMP (cAMP), a key, second messenger that regulates diverse physiological responses including sugar and lipid metabolism, olfaction, and cell growth and differentiation. Most adenylyl cyclase activity in mammalian tissues is found in plasma membrane preparations with the exception of the ...
Shui-Zhong, Yan, Wei-Jen, Tang
openaire   +2 more sources

A soluble adenylyl cyclase from sea urchin spermatozoa

Gene, 2005
A previously identified, calmodulin-binding, sea urchin sperm flagellar adenylyl cyclase (AC) was cloned and sequenced and found to be a homologue of mammalian sperm soluble adenylyl cyclase (sAC). Compared to the mammalian sAC, the sea urchin sAC (susAC) has several long amino acid insertions, some of which contain protein kinase A phosphorylation ...
Mamoru, Nomura, Carmen, Beltrán, Alberto, Darszon, Victor D, Vacquier   +3 more
openaire   +2 more sources

A seminal study of soluble adenylyl cyclase

Nature Structural & Molecular Biology, 2005
In mammals, a soluble bicarbonate-regulated adenylyl cyclase is required for sperm fertility. Crystal structures of a cyanobacterial cousin provide new insights into the molecular mechanisms of activation and catalysis in soluble adenylyl cyclase and other class III nucleotidyl cyclases.
openaire   +1 more source

[Soluble forms of adenylyl cyclases of spermatozoa].

Tsitologiia, 2015
Soluble (cytosolic) forms of adenylyl cyclases (sAC), the enzymes catalyzing the conversion of ATP to the second messenger cAMP, play a key role in the regulation of spermatogenesis, control maturation of spermatozoa in the epididymis and their capacitation in the female genital tract, which determines their ability to fertilize.
A O, Shpakov, K V, Derkach
openaire   +1 more source

Two domains are critical for the nuclear localization of soluble adenylyl cyclase

Biochimie, 2006
Soluble adenylyl cyclase (sAC) is a newly identified source of cyclic adenosine 3',5'-monophosphate (cAMP). Unlike the well-known transmembrane adenylyl cyclases (tmACs), sAC locates to the nucleus, mitochondria and microtubules. For most cAMP-signaling microdomains, there is always an AC nearby, for example tmAC.
Qiping, Feng, Yongwei, Zhang, Yunfeng, Li, Zhuo, Liu, Jin, Zuo, Fude, Fang   +5 more
openaire   +2 more sources

Specific expression of soluble adenylyl cyclase in male germ cells

Molecular Reproduction and Development, 2000
The cAMP signaling pathway is an important mediator of extracellular signals in organisms from prokaryotes to higher eukaryotes. In mammals two types of adenylyl cyclase synthesize cAMP; a ubiquitous family of transmembrane isoforms regulated by G proteins in response to extracellular signals, and a recently isolated soluble enzyme insensitive to ...
M L, Sinclair, X Y, Wang, M, Mattia, M, Conti, J, Buck, D J, Wolgemuth, L R, Levin   +6 more
openaire   +2 more sources