Results 21 to 30 of about 19,255 (216)

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit [PDF]

iScience
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova   +8 more
doaj   +2 more sources

Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. [PDF]

Invest Ophthalmol Vis Sci, 2016
Shaw PX, Fang J, Sang A, Wang Y, Kapiloff MS, Goldberg JL.   +5 more
europepmc   +3 more sources

Soluble adenylyl cyclase is an acid-base sensor in epithelial base-secreting cells. [PDF]

Am J Physiol Cell Physiol, 2016
Roa JN, Tresguerres M.
europepmc   +2 more sources

Intracellular cAMP signaling by soluble adenylyl cyclase [PDF]

Kidney International, 2011
Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is distinct from the more widely studied source of cAMP, the transmembrane adenylyl cyclases (tmACs); its activity is uniquely regulated by bicarbonate anions, and it is distributed throughout the cytoplasm ...
Martín Tresguerres, Lonny R. Levin, Jochen Buck   +2 more
openalex   +3 more sources

Updating the Mechanism of Bicarbonate (HCO₃^-) Activation of Soluble Adenylyl Cyclase (sAC). [PDF]

Int J Mol Sci
Ferreira J, Belliveau H, Steegborn C, Buck J, Levin LR.   +4 more
europepmc   +3 more sources

The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. [PDF]

Oncotarget, 2016
Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH.   +16 more
europepmc   +3 more sources

β-Nicotinamide adenine dinucleotide (β-NAD) acts as a bronchodilator. [PDF]

PLoS ONE
Introductionβ-Nicotinamide adenine dinucleotide (β-NAD) is recognized as a sympathetic neurotransmitter that relaxes vascular and intestinal smooth muscle through purinergic receptor pathways. In the lung, β-NAD has been associated with anti-inflammatory
Innokentij Jurastow, Silke Wiegand, Amir Rafiq, Anna Zakrzewicz, Sandra Engel, Adriano Sanna, Daniel von der Beck, Walter Klepetko, Andreas Hecker, Andreas Günther, Moritz Bünemann, Gabriela Krasteva-Christ, Maryam Keshavarz   +12 more
doaj   +2 more sources

Regulation of ionized calcium concentration in mitochondria matrix in the absence of exogenous Са(2+) [PDF]

The Ukrainian Biochemical Journal, 2021
Functional activity of mitochondria depends on ionized calcium content in its matrix. Thus, investigation of the ways to influence Ca2+ transport and accumulation in these organelles is an urgent issue.
A. V. Sylenko, S. G. Shlykov, L. G. Babich, О. Yu. Chunikhin, S. O. Kosterin   +4 more
doaj   +1 more source

Pharmacological Distinction between Soluble and Transmembrane Adenylyl Cyclases [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2013
The second messenger cAMP is involved in a number of cellular signaling pathways. In mammals, cAMP is produced by either the hormonally responsive, G protein-regulated transmembrane adenylyl cyclases (tmACs) or by the bicarbonate- and calcium-regulated soluble adenylyl cyclase (sAC).
Jacob Bitterman, Lavoisier Ramos‐Espiritu, Ana Díaz, Lonny R. Levin, Jochen Buck   +4 more
  +6 more sources

Soluble adenylyl cyclase in health and disease. [PDF]

Biochim Biophys Acta, 2014
The second messenger cAMP is integral for many physiological processes. Soluble adenylyl cyclase (sAC) was recently identified as a widely expressed intracellular source of cAMP in mammalian cells. sAC is evolutionary, structurally, and biochemically distinct from the G-protein-responsive transmembranous adenylyl cyclases (tmAC).
Schmid A, Meili D, Salathe M.
europepmc   +3 more sources