Soluble adenylyl cyclase of sea urchin spermatozoa. [PDF]
Biochim Biophys Acta, 2014 Fertilization, a key step in sexual reproduction, requires orchestrated changes in cAMP concentrations. It is notable that spermatozoa (sperm) are among the cell types with extremely high adenylyl cyclase (AC) activity. As production and consumption of this second messenger need to be locally regulated, the discovery of soluble AC (sAC) has broadened ...
Vacquier VD +4 more
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Autoinhibitory regulation of soluble adenylyl cyclase [PDF]
Molecular Reproduction and Development, 2006 Soluble adenylyl cyclase is an evolutionarily conserved bicarbonate sensor that plays a crucial role in cAMP dependent processes that occur during mammalian fertilization. sAC protein is expressed at the highest levels in male germ cells, and is found to occur as one of two known isoforms: a truncated protein (sAC(t)) that consists almost exclusively ...
James A, Chaloupka +4 more
openaire +2 more sources
The role of R21 expression in differential diagnosis of melanocytic lesions
Indian Journal of Pathology and Microbiology, 2023 Background: Cyclic adenosine monophosphate (cAMP) is an intracellular signal transmitter involved in the regulation of melanocyte growth, proliferation, and melanogenesis.
Didem Turcan +2 more
doaj +1 more source
Induction of RAGE shedding by activation of G protein-coupled receptors. [PDF]
PLoS ONE, 2012 The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory conditions and Alzheimers disease.
Verena V Metz +3 more
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Control of outflow resistance by soluble adenylyl cyclase. [PDF]
J Ocul Pharmacol Ther, 2014 Abstract Glaucoma is a leading cause of blindness in the United States affecting as many as 2.2 million Americans. All current glaucoma treatment strategies aim to reduce intraocular pressure, even in patients with normal tension glaucoma. Typically, this is accomplished by reducing the rate of aqueous flow by limiting aqueous production or enhancing ...
Lee YS, Marmorstein AD.
europepmc +4 more sources
Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose. [PDF]
PLoS ONE, 2012 The bacterial adenylyl cyclase toxins CyaA from Bordetella pertussis and edema factor from Bacillus anthracis as well as soluble guanylyl cyclase α(1)β(1) synthesize the cyclic pyrimidine nucleotide cCMP.
Andreas Hammerschmidt +9 more
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Soluble adenylyl cyclase is essential for proper lysosomal acidification. [PDF]
J Gen Physiol, 2016 Lysosomes, the degradative organelles of the endocytic and autophagic pathways, function at an acidic pH. Lysosomes are acidified by the proton-pumping vacuolar ATPase (V-ATPase), but the molecular processes that set the organelle’s pH are not completely understood. In particular, pH-sensitive signaling enzymes that can regulate lysosomal acidification
Rahman N +4 more
europepmc +4 more sources
Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function. [PDF]
Respir Res, 2016 Ivonnet P +3 more
europepmc +2 more sources
Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation. [PDF]
, 2017 ObjectivesIncreased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways.
Gao, Mei Hua +5 more
core +9 more sources
Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. [PDF]
PLoS ONE, 2012 The most severe form of human malaria is caused by the parasite Plasmodium falciparum. The second messenger cAMP has been shown to be important for the parasite's ability to infect the host's liver, but its role during parasite growth inside erythrocytes,
Eric Salazar +6 more
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