Results 51 to 60 of about 19,134 (215)

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

Emerging Role of cAMP/AMPK Signaling

Cells, 2022
The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis.
Muhammad Aslam, Yury Ladilov
doaj   +1 more source

Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]

, 1999
RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S., Caron, Joan M., Chen, Ching-Kang, Druey, Kirk M., Jones, Teresa L. Z., Ugur, Ozlem   +5 more
core   +1 more source

2321

Journal of Clinical and Translational Science, 2017
OBJECTIVES/SPECIFIC AIMS: Our objective is to study the role of soluble adenylyl cyclase in the melanocyte regulation of pigment in response to ultraviolet radiation. Melanocytes are specialized cells that produce melanin in organelles called melanosomes,
Koji Ota, Dalee Zhou, Jonathan Zippin
doaj   +1 more source

Soluble adenylyl cyclase

, 2018
\(\bf Aims\) In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood. Here we investigate whether
Schirmer, Ilona, Bualeong, Tippaporn (Dr. rer. nat.), Budde, Heidi (M. Sc.), Cimiotti, Diana (Dr. rer. nat.), Appukuttan, Avinash (Dr. rer. nat.), Klein, Nicole (M. Sc.), Steinwascher, Philip (M.Sc.), Reusch, Hans-Peter (Dr. med.), Mügge, Andreas (Prof. Dr. med.), Meyer, Rainer (Apl. Prof. Dr. rer. nat.), Ladilov, Yuri, Jaquet, Kornelia (Prof. Dr. rer. nat.)   +11 more
openaire   +5 more sources

Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper Channels in Human and Mouse Sperm

Frontiers in Cell and Developmental Biology, 2021
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization.
Juan J. Ferreira, Juan J. Ferreira, Pascale Lybaert, Lis C. Puga-Molina, Celia M. Santi, Celia M. Santi   +5 more
doaj   +1 more source

Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]

, 1998
Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F., Walikonis, Randall S.   +1 more
core   +1 more source

Soluble Adenylyl Cyclase Is Not Required for Axon Guidance to Netrin-1 [PDF]

The Journal of Neuroscience, 2008
During development, axons are directed to their targets by extracellular guidance cues. The axonal response to the guidance cue netrin-1 is profoundly influenced by the concentration of cAMP within the growth cone. In some cases, cAMP affects the sensitivity of the growth cone to netrin-1, whereas in others it changes the response to netrin-1 from ...
Simon W. Moore, Karen Lai Wing Sun, Fang Xie, Philip Barker, Marco Conti, Timothy E. Kennedy   +5 more
openalex   +4 more sources

In vivo characterization of sAC null sperm

Frontiers in Cell and Developmental Biology, 2023
Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and ...
Carla Ritagliati, Sylvia Ayoub, Melanie Balbach, Jochen Buck, Lonny R. Levin   +4 more
doaj   +1 more source

Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. [PDF]

PLoS ONE, 2012
An early feature of acute pancreatitis is activation of zymogens, such as trypsinogen, within the pancreatic acinar cell. Supraphysiologic concentrations of the hormone cholecystokinin (CCK; 100 nM), or its orthologue cerulein (CER), induce zymogen ...
Thomas R Kolodecik, Christine A Shugrue, Edwin C Thrower, Lonny R Levin, Jochen Buck, Fred S Gorelick   +5 more
doaj   +1 more source