Results 61 to 70 of about 19,134 (215)

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. [PDF]

Nat Chem Biol, 2016
The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally in independently regulated microdomains. In mammalian cells, two types of adenylyl cyclase generate cAMP: G-protein-regulated transmembrane adenylyl cyclases and bicarbonate-, calcium- and ATP ...
Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C, Zippin JH, van den Heuvel J, Glickman JF, Steegborn C, Levin LR, Buck J.   +15 more
europepmc   +5 more sources

Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

eLife, 2023
Mitochondrial ATP production in ventricular cardiomyocytes must be continually adjusted to rapidly replenish the ATP consumed by the working heart. Two systems are known to be critical in this regulation: mitochondrial matrix Ca2+ ([Ca2+]m) and blood ...
Maura Greiser, Mariusz Karbowski, Aaron David Kaplan, Andrew Kyle Coleman, Nicolas Verhoeven, Carmen A Mannella, W Jonathan Lederer, Liron Boyman   +7 more
doaj   +1 more source

Neuronal expression of soluble adenylyl cyclase in the mammalian brain. [PDF]

Brain Res, 2013
Cyclic 3',5'-adenosine monophosphate (cAMP) is a critical and ubiquitous second messenger involved in a multitude of signaling pathways. Soluble adenylyl cyclase (sAC) is a novel source of cAMP subject to unique localization and regulation. It was originally discovered in mammalian testis and found to be activated by bicarbonate and calcium.
Chen J, Martinez J, Milner TA, Buck J, Levin LR.   +4 more
europepmc   +4 more sources

Purification and Characterization of a Soluble Form of Mammalian Adenylyl Cyclase [PDF]

Journal of Biological Chemistry, 1996
An engineered, soluble form of mammalian adenylyl cyclase has been expressed in Escherichia coli and purified by three chromatographic steps. The enzyme utilizes one molecule of ATP to synthesize one molecule of cyclic AMP and pyrophosphate at a maximal specific activity of 12.8 micromol/min/mg, corresponding to a turnover number of 720 min-1. Although
C W, Dessauer, A G, Gilman
openaire   +2 more sources

Extracellular regulation of sperm transmembrane adenylyl cyclase by a forward motility stimulating protein. [PDF]

PLoS ONE, 2014
Forward motility stimulating factor (FMSF), a glycoprotein isolated from buffalo serum, binds to the surface of the mature sperm cells to promote their progressive motility.
Souvik Dey, Debarun Roy, Gopal C Majumder, Debdas Bhattacharyya   +3 more
doaj   +1 more source

Endocrinology and the brain: Corticotropin-Releasing Hormone signaling [PDF]

, 2017
Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral
Armando, Natalia Giannina, Dos Santos Claro, Paula Ayelen, Inda, María Carolina, Silberstein Cuña, Susana Iris   +3 more
core   +2 more sources

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

Journal of Cardiovascular Development and Disease, 2018
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity,
Sofya Pozdniakova, Yury Ladilov
doaj   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Adenylyl Cyclase in Ocular Health and Disease: A Comprehensive Review

Biology
Adenylyl cyclases (ACs) are a group of enzymes that convert adenosine-5′-triphosphate (ATP) to cyclic adenosine 3′,5′ monophosphate (cAMP), a vital and ubiquitous signalling molecule in cellular responses to hormones and neurotransmitters. There are nine
Polly Thompson, Virginija Vilkelyte, Malgorzata Woronkowicz, Mitra Tavakoli, Piotr Skopinski, Harry Roberts   +5 more
doaj   +1 more source