Results 71 to 80 of about 19,134 (215)

Photocycle features of heterologously expressed and assembled eukaryotic flavin-binding BLUF domains of photoactivated adenylyl cyclase (PAC), a blue-light receptor in Euglena gracilis [PDF]

, 2005
Photoactivated adenylyl cyclase (PAC) is a recently discovered blue-light photoreceptor that mediates photomovement in Euglena gracilis (Iseki et al., Nature, 2002, 415, 1047-1051). PAC appears to be a heterotetramer composed of two FAD-binding subunits (
HIGASHI Shoichi, ISEKI Mineo, ITO Shinji, MURAKAMI Akio, NISHINA Yasuzo, SATO Kyosuke, SHIGA Kiyoshi, TAKAHASHI Tetsuo, WATANABE Masakatsu, 正勝 渡辺   +9 more
core   +2 more sources

The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase [PDF]

The EMBO Journal, 2001
A new Dictyostelium discoideum cyclase gene was identified that encodes a protein (sGC) with 35% similarity to mammalian soluble adenylyl cyclase (sAC). Gene disruption of sGC has no effect on adenylyl cyclase activity and results in a >10-fold reduction in guanylyl cyclase activity.
Roelofs, J, Meima, M, Schaap, P, Van Haastert, PJM   +3 more
openaire   +3 more sources

The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis. [PDF]

Dig Dis, 2017
<b><i>Background:</i></b> Primary biliary cholangitis (PBC; previously referred to as primary biliary cirrhosis) is a chronic fibrosing cholangiopathy with the signature of an autoimmune disease and features of intrahepatic cholestasis. Immunosuppressing treatments are largely unsuccessful. Responsiveness to ursodeoxycholic acid
Chang JC, Beuers U, Oude Elferink RP.
europepmc   +4 more sources

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]

, 2018
Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun, Ellisman, Mark H, Jeong, Seung Won, Ju, Won-Kyu, Kim, Keun-Young, Nam, Hye Seung, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +8 more
core   +2 more sources

Essential role of CFTR in PKA-dependent phosphorylation, alkalinization, and hyperpolarization during human dperm capacitation [PDF]

, 2017
Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation.
Austin, Berger, Bobadilla, Buffone, Buffone, Buffone, Buffone, Chang, Chen, Chen, Chen, Chávez, Chávez, De Jonge, De La Vega-Beltran, Demarco, Diao, Dirami, Dostmann, Ellsworth, Escoffier, Esteves, Figueiras-Fierro, Gabriel, Gadsby, Hernández-González, Ishiguro, José, Kase, Kujala, Köhn, l'Hoste, Laemmli, Leclerc, Li, Lishko, Lochner, Luconi, López-González, Ma, Melis, Mortimer, Muanprasat, Navarrete, Neill, Nishigaki, Nolan, Okamura, Rode, Schulz, Sheppard, Sorum, Stival, Stival, Tabcharani, Tang, Towbin, Visconti, Visconti, Wennemuth, Wertheimer, Xu, Zeng, Zeng   +63 more
core   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, EarlyView.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. [PDF]

, 2000
We report here that guanylyl cyclase activity is associated with two large integral membrane proteins (PfGCalpha and PfGCbeta) in the human malaria parasite Plasmodium falciparum.
Altschul, Bakalyar, Baker, Bilker, Brooks, Bzik, Cavalier-Smith, Chinkers, Cowman, Defer, Devereaux, Don, Garbers, Gilman, Harte, Ishikawa, Janssens, Jencks, Kawamoto, Koch, Krupinsky, Li, Li, Li, Linder, Liu, MacLennan, Nakane, Pitt, Ripmaster, Robson, Sambrook, Sanchez, Saul, Schulkes, Schultz, Schultz, Sunahara, Sunahara, Tang, Taylor, Tesmer, Thaithong, Toyofuku, Triglia, Triglia, Triglia, Tucker, van Es, Walliker, Ward, Zhang, Zimmerman   +52 more
core   +1 more source

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation

Frontiers in Physiology, 2014
The evolutionarily conserved soluble adenylyl cyclase (sAC, adcy10) was recently identified as a unique source of cAMP in the cytoplasm and the nucleus. Its activity is regulated by bicarbonate and fine-tuned by calcium.
Jung-Chin eChang, Ronald eOude Elferink
doaj   +1 more source

Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor. [PDF]

PLoS ONE, 2013
Guanylyl cyclases (GCs) regulate many physiological processes by catalyzing the synthesis of the second messenger cGMP. The GC family consists of seven particulate GCs (pGCs) and a nitric oxide-activated soluble GC (sGC).
Kerstin Y Beste, Corinna M Spangler, Heike Burhenne, Karl-Wilhelm Koch, Yuequan Shen, Wei-Jen Tang, Volkhard Kaever, Roland Seifert   +7 more
doaj   +1 more source