Results 51 to 60 of about 1,214,481 (246)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity

Microbiome
Background The observation that the intestinal microbiota is  central in the development of IBD suggests that dietary fiber, the microbiota’s primary source of nourishment, could play a central role in these diseases.
Erica Bonazzi, Alexis Bretin, Lucile Vigué, Fuhua Hao, Andrew D. Patterson, Andrew T. Gewirtz, Benoit Chassaing   +6 more
doaj   +1 more source

Self-Referencing Fiber-Optic Intensity Sensors Using Ring Resonators and Fiber Bragg Gratings [PDF]

, 2006
An improved ring resonator self-referencing technique in a new reflection configuration for remote fiber-optic intensity sensors is demonstrated using fiber Bragg gratings. Sensor sensitivity doubles and a single fiber lead is used.
Sánchez-Pena, José Manuel, Vázquez García, María Carmen, Montalvo García, Julio, Sánchez Montero, David Ricardo   +3 more
core   +2 more sources

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

Effects of fiber properties on shrinkage of fiber/PMMA composite-based bone cements

, 2010
Fiber/polymethylmetacrylate (PMMA) composite bone cements were prepared with various fiber types (polyester and kevlar) in %1, 2 and 3 volumes. The shrinkage of the fiber/PMMA composite patterns were then calculated among 150 days. Results indicated that
Ulcay, Yusuf, Eren, Semiha
core   +1 more source

Physicochemical Characterization of Soluble and Insoluble Fibers from Berry Pomaces

Gels
Berry pomace is a valuable source of dietary fiber (DF) with promising applications in functional food development. This study aimed to evaluate and compare the technological and rheological properties of soluble (SDF) and insoluble (IDF) fiber fractions
Jolita Jagelavičiūtė, Simona Šimkutė, Aurelija Kairė, Gabrielė Kaminskytė, Loreta Bašinskienė, Dalia Čižeikienė   +5 more
doaj   +1 more source

Superlubricity and Corrosion Inhibition Properties of Solvate Ionic Liquids in Hybrid Carbon Fiber Reinforced Plastic–Steel Interfaces

Advanced Engineering Materials, EarlyView.
Solvate ionic liquids lubrication reduced the coefficient of friction by ∼60% compared to dry sliding, reaching steady‐state values as low as 0.04–0.05. Corrosion weight‐loss measurements in 1 M HCl further demonstrated significant inhibition behavior, with only 100 ppm of [Li(G3)][TFSI] (∼68.5 μL/L) reducing corrosion‐product weight loss by 63 ...
Sameh Dabees, Timothy Harte, Bhagya Dharmasiri, Y. Athulya Wickramasingha, David J. Hayne, Daniel J. Eyckens, Luke C. Henderson   +6 more
wiley   +1 more source

Effects of fiber or probiotic yogurt supplementation on intestinal barrier integrity in constipation predominant irritable bowel syndrome

Gülhane Tıp Dergisi
Aims: This study aimed to evaluate the effects of different dietary treatments on intestinal integrity in female subjects aged 19-50 years with a previous diagnosis of constipation-predominant irritable bowel syndrome (IBS).
Nuket Emine Ünsal, Gamze Akbulut, Mustafa Gülşen   +2 more
doaj   +1 more source

Characteristics of Q-switched cladding-pumped ytterbium-doped fiber lasers with different high-energy fiber designs

, 2001
We theoretically and experimentally analyze Q-switched cladding pumped ytterbium-doped fiber lasers designed for high pulse energies. We compare the extractable energy from two high-energy fiber designs: (1) single- or few-moded low-NA large mode area ...
Alvarez-Chavez, J.A., Clarkson, W.A., Nilsson, J., Offerhaus, H.L., Turner, P.W., Renaud, Cyril C., Richardson, D.J., Grudinin, A.B.   +7 more
core   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source