Results 101 to 110 of about 463,492 (156)

Yc-1 Potentiates the Antiplatelet Effect of Hydrogen Peroxide Via Sensitization of Soluble Guanylate Cyclase

, 2009
the present study, we showed that 3-(5'-hydroxymethyl-2'- furyl)-1-benzyl indazole (YC-1), a nitric oxide (NO)- independent activator of soluble guanylate cyclase, could potentiate H2O2-induced inhibition of platelet aggregation and increase of platelet ...
Wu, Chin-Chung; Kuo, Sheng-Chu; Lee, Fang-Yu; Teng, Che-Ming, 鄧哲明   +1 more
core  

The efficacy and safety of soluble guanylate cyclase stimulators in patients with heart failure: A systematic review and meta-analysis. [PDF]

Medicine (Baltimore), 2018
Zheng X, Zheng W, Xiong B, Huang J.
europepmc   +1 more source

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension

, 2008
Alterations of the nitric oxide receptor, soluble guanylate cyclase (sGC) may contribute to the pathophysiology of pulmonary arterial hypertension (PAH). In the present study, the expression of sGC in explanted lung tissue of PAH patients was studied and
Muller, D., Dingendorf, A., Schluter, K.D., Mittendorf, J., Middendorff, R., Ghofrani, H.A., Pullamsetti, S.S., Kolosionek, E., Grimminger, F., Klepetko, W., Stasch, J.P., Kaulen, C., Schermuly, R.T., Dumitrascu, R., Seeger, W., Weissmann, N., Hackemack, S.   +16 more
core  

The discovery and characterization of novel soluble guanylate cyclase stimulators [PDF]

BMC Pharmacol Toxicol, 2015
Masferrer J.
europepmc   +1 more source

Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells. [PDF]

Cancer Lett, 2017
Tuttle TR, Takiar V, Kumar B, Kumar P, Ben-Jonathan N.   +4 more
europepmc   +1 more source

Soluble guanylate cyclase induces cranial vasodilation and headache in adults:a randomized trial.

The role of cranial vasodilation in headache pathogenesis sparks ongoing debate. Soluble guanylate cyclase is an enzyme that catalyses the conversion of guanosine triphosphate to cyclic guanosine monophosphate, leading to relaxation of vascular smooth ...
Ashina, Håkan, Ashina, Messoud, Abdulla, Jawdat, Christensen, Casper E., Amin, Faisal M., Domínguez-Moreno, Rogelio, Rasmussen, Nadja B., Carlsen, Jørn   +7 more
core   +1 more source

Phase 1 Study of MK-5475, an Inhaled Soluble Guanylate Cyclase Stimulator, in Participants with Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease [PDF]

Ednan K Bajwa,1 Dawn Cislak,1 Amit Kumar,1 Dan Li,1 Eric J Messina,1 Tom Reynders,2 Jean-François Denef,2 Vasile Corcea,3 Ketan P Buch,4 Eseng Lai,1 S Aubrey Stoch1 1MRL, Merck & Co., Inc., Rahway, NJ, USA; 2Translational Medicine, MSD Belgium, Brussels,
Corcea V, Messina EJ, Bajwa EK, Cislak D, Li D, Reynders T, Lai E, Denef JF, Buch KP, Stoch SA, Kumar A   +10 more
core  

Japanese Nationwide Survey of New Heart Failure Drug Prescriptions by Pediatric Cardiologists. [PDF]

Circ Rep
Muneuchi J, Collaborators.
europepmc   +1 more source

Efficacy and Safety of Vericiguat in Heart Failure: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Kilic A, Saxena A, Khan B, Rupanshu R, Mann RS, Chopra I.   +5 more
europepmc   +1 more source

The predictive value of the TAPSE/PASP ratio for major adverse cardiovascular events in patients with chronic heart failure: evidence from a prolonged follow-up cohort. [PDF]

Ann Med
Wang X, Li J, He P, Li T, Cheng W, Wei Z.   +5 more
europepmc   +1 more source