Results 81 to 90 of about 463,492 (156)
MedComm, Volume 7, Issue 10, October 2026.Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan +6 more
wiley +1 more source
Pulmonary Circulation, Volume 16, Issue 4, October 2026.ABSTRACT This study quantified the recent real‐world burden of pulmonary arterial hypertension (PAH) using US real‐world data. Adults (18+) with treated PAH were identified from the MarketScan Commercial/Medicare Databases using a claims‐based algorithm requiring pulmonary hypertension diagnosis, PAH‐specific treatment, and right heart catheterization ...
Ashwin Ravichandran +6 more
wiley +1 more source
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Cancer cells undergo metabolic reprogramming to sustain proliferation, resist apoptosis, and adapt to oxidative stress. In the present study, we comparatively evaluated the anticancer effects of four medicinal plant extracts (Inula helenium, Hypericum alpestre, Rumex obtusifolius, and Alchemilla smirnovii) on HeLa cervical cancer cells, with ...
Mery Kocharyan +6 more
wiley +1 more source
Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 3, September 2026.Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao +8 more
wiley +1 more source
THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES [PDF]
, 2010 Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes.
TOWNSEND, PHILIP,DAVID +1 more
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Soluble Guanylate Cyclase Modulators and Inhibitors for Neurological Disorders [PDF]
, 2016 Guanylate cyclase (GC) is divided into two categories: membrane bound particulate guanylate cyclase (pGC) and cytoplasmic soluble guanylate cyclase (sGC).
Ronak P. Gandhi (7998959)
core +4 more sources
Guanylate cyclase activity in permeabilized Dictyostelium discoideum cells [PDF]
, 1996 Dictyostelium discoideum cells respond to chemoattractants by transient activation of guanylate cyclase. Cyclic GMP is a second messenger that transduces the chemotactic signal. We used an electropermeabilized cell system to investigate the regulation of
Schulkes, C.C.G.M. +3 more
core +2 more sources
Soluble Guanylate Cyclase Stimulators in Heart Failure. [PDF]
Cureus, 2021 Kansakar S +7 more
europepmc +1 more source
An investigation of the response of a model class IIIA Adenyly Cyclase to carbon dioxide [PDF]
, 2009 Adenylyl cyclase catalyses the conversion of adenosine triphosphate into 3’,5'-cyclic adenosine monophosphate and pyrophosphate. Adenylyl cyclases are grouped into six distinct Classes based on amino acid sequence similarity.
Holliday, Phillip
core
Pharmacology Research & PerspectivesHeart failure (HF) is a leading cause of morbidity and mortality, often driven by prolonged exposure to pathological stimuli such as pressure and volume overload.
Adriana Martišková +8 more
doaj +1 more source