Results 61 to 70 of about 463,492 (156)

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Efeito inibitório duradouro do óxido nítrico sobre a agregação plaquetária [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA agregação plaquetária ocorre fisiologicamente para ocluir lesões em vasos ou em condições anormais como na ...
Gonçalves, Muryel de Carvalho
core  

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

New Generation of sGC Stimulators: Discovery of Imidazo[1,2‑a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension

, 2023
Herein, we describe the identification, chemical optimization, and preclinical characterization of novel soluble guanylate cyclase (sGC) stimulators. Given the very broad therapeutic opportunities for sGC stimulators, new tailored molecules for distinct ...
Volkhart Li (4100524), Holger Paulsen (2325505), Peter Sandner (819104), Gorden Redlich (2410774), Alexey V. Gromov (15208599), Alexandros Vakalopoulos (8659995), Frank Wunder (254278), Niels Lindner (14651979), Dirk Thomas (15208611), Alexander Straub (1722913), Hubert Trübel (4100551), Walter Kroh (2325502), Andreas Knorr (226427), Eva Becker-Pelster (15208605), Dieter Lang (4100539), Martina Schaefer (9568930), Volker Geiss (4100536), Donald Bierer (4693777), Philipp Buchgraber (2063245), Jörg Gries (15208602), Johannes-Peter Stasch (142873), Ingo V. Hartung (2281924), Jorma Hassfeld (1496128), Joachim Mittendorf (4100545), Marian Raschke (8769701), Rolf Jautelat (4100527), Damian Brockschnieder (15208608), Markus Follmann (1585201), Thomas Mondritzki (4100530)   +28 more
core   +2 more sources

Predicting Response to Switching From Phosphodiesterase Type 5 Inhibitor to Riociguat in Patients With Pulmonary Arterial Hypertension: Biomarker and Responder Analysis of the RESPITE and REPLACE Studies

Pulmonary Circulation
This exploratory analysis assessed whether plasma biomarkers predict the response to switching from phosphodiesterase type 5 inhibitors (PDE5is) to the soluble guanylate cyclase stimulator riociguat in patients with pulmonary arterial hypertension ...
James R. Klinger, Hikmet Al‐Hiti, Sung‐A. Chang, Hyuk J. Chang, Hossein‐Ardeschir Ghofrani, Ekkehard Grünig, Marius M. Hoeper, Pavel Jansa, Jaquelina Ota‐Arakaki, Tomas Pulido, Gérald Simonneau, Carmine Dario Vizza, Claudia Rahner, Christian Meier, Gisela Meyer   +14 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Protocol for a multicentre, double-blind, randomised, placebo-controlled trial of riociguat on peak cardiac index during exercise in patients with chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty (THERAPY-HYBRID-BPA trial)

BMJ Open, 2023
Objectives Balloon pulmonary angioplasty (BPA) and medical therapy, such as soluble guanylate cyclase stimulators, are recommended treatments for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are ineligible for pulmonary ...
Akiko M Saito, Hiroya Hashimoto, Masahiro Sekimizu, Hiromi Matsubara, Yu Taniguchi, Takumi Inami, Hiroto Shimokawahara, Kayoko Kubota   +7 more
doaj   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Tonic and phasic nitric oxide signals in hippocampal long-term potentiation [PDF]

, 2006
Nitric oxide ( NO) participates in long-term potentiation (LTP) and other forms of synaptic plasticity in many different brain areas but where it comes from and how it acts remain controversial.
Hopper, RA, Garthwaite, J
core  

The nitric oxide–soluble guanylate cyclase–cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase

European Respiratory Review
The nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) pathway plays a key role in the pathogenesis of pulmonary hypertension (PH).
Raymond L. Benza, Ekkehard Grünig, Peter Sandner, Johannes-Peter Stasch, Gérald Simonneau   +4 more
doaj   +1 more source