Results 31 to 40 of about 82,478 (265)

Genetic Variants and Soluble Isoforms of PD-1/PD-L1 as Novel Biomarkers for Pancreatic Ductal Adenocarcinoma (PDAC) Susceptibility and Prognosis

Biomedicines
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive neoplasm often diagnosed at advanced stages. Immune checkpoint molecules, particularly programmed cell death protein-1 (PD-1) and its ligand PD-L1, are pivotal in tumor immune ...
Marwa Hassan, Walaa H. El-Maadawy, Yasmine Elhusseny, Fatma Elbatol Agamy, Sally A. Fahim, Mahmoud Balata   +5 more
doaj   +2 more sources

Assessing the Clinical Relevance of Soluble PD-1 and PD-L1: A Multi-Cohort Study Across Diverse Tumor Types and Prognostic Implications

Biomedicines
Background/Objectives: Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have revolutionized cancer immunotherapy, however the clinical relevance of their soluble forms (sPD-1 and sPD-L1) remains less studied. Soluble PD-1 and PD-L1 have been
Nikolay E. Kushlinskii, Olga V. Kovaleva, Alexei N. Gratchev, Alexander A. Alferov, Yurii B. Kuzmin, Nikolai Y. Sokolov, Dmitry A. Tsekatunov, Irina B. Ryzhavskaya, Igor N. Kuznetsov, Dmitry N. Kushlinskii, Zaman Z. Mamedli, Ivan S. Stilidi   +11 more
doaj   +2 more sources

Measurement of soluble PD-1 and soluble PD-L1 as well as PD-L1 and PD-1 from perioperative patients with gastric carcinoma

Japanese Journal of Clinical Oncology, 2022
Abstract Background Till now, no experiment has been performed to detect programmed death ligand 1 (PD-L1)/programmed death 1 (PD-1), soluble PD-L1/soluble PD-1 simultaneously in perioperative patients of gastric carcinoma.
Hangzhi Wei, Fahong Wu, Yudong Mao, Youcheng Zhang, Guangxian Leng, Jia Wang, Wei Zhang, Tianwei Wang   +7 more
openaire   +2 more sources

Soluble PD-L1 is a promising disease biomarker but does not reflect tissue expression in classic Hodgkin lymphoma [PDF]

, 2021
Individually, tissue and soluble markers involved in the programmed cell death protein 1/programmed death-ligand (PD-1/PD-L) axis have been described as biomarkers with clinical value in classical Hodgkin lymphoma (cHL).
van den Berg, Anke, Alsada, Zainab N D, Diepstra, Arjan; id_orcid, Veldman, Johanna; id_orcid, Arjan Diepstra, Zainab N. D. Alsada, Johanna Veldman, Veldman, Johanna, Visser, Lydia, Anke van den Berg, van den Berg, Anke; id_orcid, Wouter J. Plattel, Plattel, Wouter J, Diepstra, Arjan, Lydia Visser, Plattel, Wouter J; id_orcid, Visser, Lydia; id_orcid   +16 more
core   +1 more source

Soluble PD-L1: a potential dynamic predictive biomarker for immunotherapy in patients with proficient mismatch repair colorectal cancer

Journal of Translational Medicine, 2023
Background Circulating soluble programmed death ligand 1 (sPD-L1) can negatively regulate T-cell function and serve as a prognostic or predictive marker in a variety of cancers.
Yinjun He, Xiang Zhang, Ming Zhu, Wenguang He, Hanju Hua, F. Ye, Xile Zhou, Nan Chen, Yandong Li, W. Zhong, Guosheng Wu, Hui Cai, Weiqin Jiang   +12 more
semanticscholar   +1 more source

Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke

Brain, behavior, and immunity, 2023
Acute cerebral ischemia triggers a profound inflammatory response. While macrophages polarized to an M2-like phenotype clear debris and facilitate tissue repair, aberrant or prolonged macrophage activation is counterproductive to recovery. The inhibitory
Jennifer E Kim, Ryan P. Lee, Eli Yazigi, Lyla Atta, J. Feghali, Ayush Pant, Aanchal Jain, Idan Levitan, Eileen Kim, Kisha K Patel, N. Kannapadi, Pavan Shah, Adnan Bibic, Zhipeng Hou, J. Caplan, L. F. Gonzalez, Judy Huang, Risheng Xu, Jean Fan, Betty Tyler, Henry Brem, V. Boussiotis, Lauren L. Jantzie, Shenandoah Robinson, Raymond C. Koehler, Michael Lim, R. Tamargo, Christopher M. Jackson   +27 more
semanticscholar   +1 more source

Analysis of the cellular and soluble immune checkpoint components PD-L1 and sPD-L1 in renal cell carcinoma

, 2021
Das Nierenzellkarzinom (RCC) zählt in Deutschland zu den zehn am häufigsten vorkommenden Tumor-entitäten. Während bei lokal begrenzten Tumoren eine operative Tumorresektion mit kurativer Zielsetzung möglich ist, führt es im metastasierten ...
Wegner, Moritz Justus Philipp
core   +1 more source

Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy [PDF]

American Journal of Reproductive Immunology, 2022
AbstractProblemThe aim of this study was to evaluate the soluble programmed death‐ligand (sPD‐L1) and soluble B7‐H4 (sB7‐H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies.Method of the studysPD‐L1 and sB7‐H4 levels were determined with enzyme‐linked immunosorbent assay (ELISA). The patients (n = 26)
Pawel Mach, Angela Köninger, Beatrix Reisch, Rainer Kimmig, Alexandra Gellhaus   +4 more
openaire   +3 more sources

PD-L1⁺ virions can be produced from PD-L1⁺ CD4 T cells or monocyte-derived macrophages in vitro.

, 2022
Activated CD4 T cells or MDM from HIV-uninfected individuals (N = 7) were exposed or not to HIV lab-derived variants in presence or in absence of emtricitabin.
Riddhima Banga (634344), Matthias Cavassini (146654), Laurent Perez (3458786), Pauline Nortier (13001930), Francesco Andrea Procopio (7022861), Craig Fenwick (1792990), Andrea Mastrangelo (11594374), Jean Daraspe (5574758), Matthieu Perreau (268148), Olivia Munoz (7022867), Rachel Schelling (13001927), Khalid Ohmiti (430647)   +11 more
core   +1 more source

Soluble monomeric human programmed cell death-ligand 1 inhibits the functions of activated T cells

Frontiers in Immunology, 2023
IntroductionThe presence of soluble human programmed cell death-ligand 1 (shPD-L1) in the blood of patients with cancer has been reported to be negatively correlated with disease prognosis.
Zhaoduan Liang, Zhaoduan Liang, Wenfang Chen, Yunzhuo Guo, Yunzhuo Guo, Yuefei Ren, Yuefei Ren, Ye Tian, Wenxuan Cai, Yifeng Bao, Qi Liu, Peng Ding, Yi Li, Yi Li   +13 more
doaj   +1 more source