Results 11 to 20 of about 82,478 (265)

Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade [PDF]

Cancer Immunology Research, 2017
Abstract Blockade of the pathway including programmed death-ligand 1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) has produced clinical benefits in patients with a variety of cancers. Elevated levels of soluble PD-L1 (sPD-L1) have been associated with worse prognosis in renal cell carcinoma and multiple myeloma ...
Jun, Zhou, Kathleen M, Mahoney, Anita, Giobbie-Hurder, Fengmin, Zhao, Sandra, Lee, Xiaoyun, Liao, Scott, Rodig, Jingjing, Li, Xinqi, Wu, Lisa H, Butterfield, Matthias, Piesche, Michael P, Manos, Lauren M, Eastman, Glenn, Dranoff, Gordon J, Freeman, F Stephen, Hodi   +15 more
core   +4 more sources

Soluble PD-L1: From Immune Evasion to Cancer Therapy

Life
Immunotherapy has emerged as a promising approach to cancer treatment, but only a small percentage of cancer patients benefit from it. To enhance therapeutic outcomes, it is essential to understand factors influencing immune response and tumor progression.
Denisa Dragu, Laura Georgiana Necula, Coralia Bleotu, Carmen C. Diaconu, Mihaela Chivu-Economescu   +4 more
core   +5 more sources

Prognostic significance of soluble PD-L1 in prostate cancer [PDF]

Frontiers in Immunology
PurposeThe aim of this study was to assess the role of sPD-L1 and sPD-1 as potential biomarkers in prostate cancer (PCa). The association of the values of these soluble proteins were correlated to the clinical data: stage of disease, Gleason score, biochemical recurrence etc.
Margarita Zvirble, Margarita Zvirble, Zilvinas Survila, Paulius Bosas, Paulius Bosas, Neringa Dobrovolskiene, Agata Mlynska, Agata Mlynska, Gintaras Zaleskis, Jurgita Jursenaite, Dainius Characiejus, Dainius Characiejus, Vita Pasukoniene   +12 more
core   +7 more sources

Soluble PD-L1 Is an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma [PDF]

Cancers, 2021
(1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response to immune checkpoint inhibitors. We evaluated both plasma and tissue expression of PD-1 and PD-L1 in the same cohort of patients, including non-metastatic and metastatic clear ...
Gorka Larrinaga, Jon Danel Solano-Iturri, Peio Errarte, Miguel Unda, Ana Loizaga-Iriarte, Amparo Pérez-Fernández, Enrique Echevarría, Aintzane Asumendi, Claudia Manini, Javier C. Angulo, José I. López   +10 more
core   +9 more sources

Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function [PDF]

Journal of Leukocyte Biology, 2020
Abstract Decidual macrophages are in close contact with trophoblast cells during placenta development, and an appropriate crosstalk between these cellular compartments is crucial for the establishment and maintenance of a healthy pregnancy.
Yong-Hong Zhang, Paulomi Aldo, Yuan You, Jiahui Ding, Janina Kaislasuo, Jesper F Petersen, Ellen Lokkegaard, Gang Peng, Michael J Paidas, Samantha Simpson, Lubna Pal, Seth Guller, Hong Liu, Ai Hua Liao, Gil Mor   +14 more
openaire   +5 more sources

Membrane PD-L1 expression and soluble PD-L1 plasma levels in idiopathic pulmonary fibrosis—a pilot study [PDF]

Journal of Thoracic Disease, 2018
Idiopathic pulmonary fibrosis (IPF) has common risk factors with cancer and significant similarities in the pathobiology process, both diseases having poor outcomes. Immune checkpoint PD-L1 has become the target of checkpoint inhibitory therapy that unleashes antitumor T cells and has revolutionized cancer treatment.
Jovanović, Dragana, Milenković, Marina, Kotur-Stevuljević, Jelena, Marković, Jelena, Ceriman, Vesna, Kontić, Milica, Skodrić-Trifunović, Vesna   +6 more
openaire   +6 more sources

Prognostic value of soluble PD-L1 and exosomal PD-L1 in advanced gastric cancer patients receiving systemic chemotherapy

Scientific Reports, 2023
AbstractThe prognostic role of soluble PD-L1 (sPD-L1) and exosomal PD-L1 (exoPD-L1) in patients with gastric cancer (GC) receiving systemic chemotherapy remains unelucidated. Thus, we examined their prognostic significance in patients with advanced GC.
Kabsoo Shin, Joori Kim, Se Jun Park, Myung Ah Lee, Jae Myung Park, Myung-Gyu Choi, Donghoon Kang, Kyo Young Song, Han Hong Lee, Ho Seok Seo, Sung Hak Lee, Bohyun Kim, Okran Kim, Juyeon Park, Nahyeon Kang, In-Ho Kim   +15 more
openaire   +4 more sources

Gene expression and soluble protein level of PD-1 and its ligands (PD-L1 and PD-L2) in endometrial cancer.

PLoS ONE
Checkpoint programmed death-1 (PD-1) and programmed cell death ligands (PD-Ls) are negative immunoregulatory molecules that assist tumour cells in evading the immune system.
Mohd Nazzary Mamat Yusof, Kah Teik Chew, Nirmala Chandralega Kampan, Abdul Muzhill Hannaan Abdul Hafizz, Mohamad Nasir Shafiee   +4 more
doaj   +2 more sources

Interferon‑γ induced PD‑L1 expression and soluble PD‑L1 production in gastric cancer

Oncology Letters, 2020
Programmed death-ligand 1 (PD-L1) plays an essential role in tumor cell escape from anti-tumor immunity in various types of cancer, including gastric cancer (GC). The present study investigated the intracellular and membrane-bound expression of PD-L1 in the GC cell lines MKN1, MKN74, KATO III and OCUM-1. Furthermore, soluble PD-L1 (sPD-L1) level in the
Imai, Yushi, Chiba, Tetsuhiro, Kondo, Takayuki, Kanzaki, Hiroaki, Kanayama, Kengo, Ao, Junjie, Kojima, Ryuta, Kusakabe, Yuko, Nakamura, Masato, Saito, Tomoko, Nakagawa, Ryo, Suzuki, Eiichiro, Nakamoto, Shingo, Muroyama, Ryosuke, Tawada, Akinobu, Matsumura, Tomoaki, Nakagawa, Tomoo, Kato, Jun, Kotani, Ai, Matsubara, Hisahiro, Kato, Naoya   +20 more
openaire   +4 more sources

High Quality Performance of Novel Immunoassays for the Sensitive Quantification of Soluble PD-1, PD-L1 and PD-L2 in Blood

Biomedicines, 2022
Programmed death-1 receptor PD-1(CD279) and its corresponding ligands PD-L1(CD274, B7-H1) and PD-L2(CD273, B7-DC) play important roles in physiological immune tolerance and for immune escape in cancer disease.
Kimberly Krueger, Zsuzsanna Mayer, Miriam Gerckens, Stefan Boeck, Peter Luppa, Stefan Holdenrieder   +5 more
doaj   +2 more sources