Results 111 to 120 of about 19,003,286 (253)

Multiplexed immune profiling and 3D co-culture assays to assess the individual checkpoint therapy response in head and neck squamous cell carcinoma

Frontiers in Oncology
BackgroundImmune checkpoint inhibitors (ICIs) have become an integral part of cancer therapy, but only a minority of patients experience durable responsiveness.
Verena Schweihofer, Verena Schweihofer, Daniela Schulz, Daniela Schulz, Raquel Blazquez, Gero Brockhoff, Gero Brockhoff, Tobias Ettl, Tobias Ettl, Mathias Fiedler, Mathias Fiedler, Sina Heimer, Sina Heimer, Juliane Schikora, Richard J. Bauer, Richard J. Bauer, Anja Kathrin Wege, Anja Kathrin Wege   +17 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Dancer from Munyarryun family in 'Laka bunkul' from the 'Dance clan' season at the Bangarra Dance Theatre studios, Pier 4/5, Walsh Bay, Sydney, November 1998 [picture] /

, 1998
Part of: Tim Webster collection of photographs of Australian dance and dancers.; Title from acquisition documentation and information supplied by photographer.; Acquired in digital format; access copies available online.; Mode of access: Internet via ...
Webster, Tim (Timothy James), 1965-
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Disseminated Kaposi sarcoma patients exhibit an expanded population of CD8+CD57+ T cells and an immunosenescence profile

Frontiers in Immunology
IntroductionKaposi’s sarcoma herpesvirus (KSHV) remains the most common opportunistic malignancy that contributes to morbidity and mortality among persons living with HIV (PLWH) worldwide.
Julio Flores-Gonzalez, Lucero A. Ramón-Luing, Beda Islas-Muñoz, Patricia Volkow-Fernández, Leslie Chavez-Galan   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The soluble form of Tim-3 (sTim-3) aggravates CD8+ T cell exhaustion and resistance to anti-PD-1 immunotherapy through CEACAM-1

The following text describes files named "fpkm.anno".This csv data file contains differential gene expression patterns and gene signatures. | File name | File category | File type | Experiment or Analysis | Related to Figure(s) | Description | fpkm.anno | sTim3-vs-MOCK.csv | fpkm list | RNA sequencing of sTim3 treated CD8+T cells and Mock CD8+T cells
Chen, Chaojia, Zhao, Fangcheng, Peng, Jiali, Zhao, Di, Xu, Liyun, Li, Huayu, Ma, Shauiya, Peng, Xueqi, Sheng, Xue, Sun, Yang, Wang, Tixiao, Dong, Haoqing, Ding, Yuming, Wu, Zhuanchang, Liang, Xiaohong, Gao, Lifen, Wang, Hongyan, Ma, Chunhong, Li, Chunyang   +18 more
openaire   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Yothu Yindi's Wityana Marika and Mangatjay Yunupingu performing at WOMADelaide, Adelaide, 1993 [picture] /

, 2004
Part of: Tim Webster collection of photographs of Australian dance and dancers.; Title from acquisition documentation.; Acquired in digital format; access copies available online.; Mode of access: Internet via World Wide ...
Webster, Tim (Timothy James), 1965-
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