Results 101 to 110 of about 19,003,286 (253)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Unlocking the roles of plasma soluble T-cell immunoglobulin and mucin domain-containing protein 3 in kidney diseases: findings from native and allograft biopsy cohorts

Molecular Biomedicine
Chronic kidney disease (CKD) and renal allograft failure represent escalating global health burdens characterized by progressive tissue remodeling. Although interstitial fibrosis and tubular atrophy (IF/TA) are the primary determinants of long-term ...
Yamei Li, Hua Zhang, Yangjuan Bai, Huan Xu, Yan Luo, Dan Ye, Xueqiao Wang, Xingxin Gong, Qu Yang, Hanjing Liu, Binqi Yang, Zheyuan Zhang, Yuxin Ye, Yunfei An, Xinhua Dai, Lanlan Wang, Yunying Shi   +16 more
doaj   +1 more source

Significant association of elevated serum galectin-9 levels with the development of non-alcoholic fatty liver disease in patients with rheumatoid arthritis

Frontiers in Medicine
BackgroundNon-alcoholic fatty liver disease (NAFLD) is prevalent among rheumatoid arthritis (RA) patients, but its pathogenesis has rarely been explored.
Po-Ku Chen, Po-Ku Chen, Wei-Fan Hsu, Wei-Fan Hsu, Cheng-Yuan Peng, Cheng-Yuan Peng, Tsai-Ling Liao, Tsai-Ling Liao, Tsai-Ling Liao, Shih-Hsin Chang, Shih-Hsin Chang, Shih-Hsin Chang, Hsin-Hua Chen, Hsin-Hua Chen, Hsin-Hua Chen, Chu-Huang Chen, Chu-Huang Chen, Der-Yuan Chen, Der-Yuan Chen, Der-Yuan Chen, Der-Yuan Chen, Der-Yuan Chen   +21 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Cohomology and the subgroup structure of a finite soluble group [PDF]

The main topic of this thesis is the discovery and study of a cohomological property of the subgroups called F-normalizers in finite soluble groups; namely, the property that with certain coefficient modules the restriction map in cohomology from a ...
Wilde, Thomas Stephen
core  

Tim-3

, 2018
Les lymphocytes T (LT) exprimant de multiples molécules de co-stimulation inhibitrices (PD-1, Tim-3, Lag-3, etc.) perdent leur activité anti-tumorale. PD-1 est une cible thérapeutique majeure dans le traitement du cancer, mais son expression isolée ne ...
Marc-Olivier Timsit, Camélia Radulescu, Charles Dariane, Clémence Granier, Yann Vano, Arnaud Mejean, Alain Gey, Virginie Verkarre, Stéphane Oudard, Charlotte Blanc, Elisabeth Fabre, Éric Tartour, Cécile Badoual   +12 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source