Results 81 to 90 of about 19,003,286 (253)

The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]

, 2010
The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Stevenson, Emma, Nimmo, Myra, Cockburn, Emma, Stevenson, Emma J, Robson-Ansley, Paula, Walshe, Ian, Nimmo, Myra A   +6 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Persistently Elevated Expression of Systemic, Soluble Co-Inhibitory Immune Checkpoint Molecules in People Living with HIV before and One Year after Antiretroviral Therapy

Pathogens
Introduction: Increasing drug resistance and the absence of a cure necessitates exploration of novel treatment strategies for people living with HIV (PLWH).
Robyn-Brooke Labuschagne Naidoo, Helen C. Steel, Annette J. Theron, Ronald Anderson, Gregory R. Tintinger, Theresa M. Rossouw   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

TIM-3 expression on lymphocytes from Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

, 2017
Gating strategy to assess for surface expression of TIM-3 on (A) CD4+ and (B) CD8+ T cells isolated from peripheral lymph nodes, lungs, livers, spleens, and brains.
Alessandro Olivi (471259), Eileen S. Kim (14997527), Haiying Xu (258277), Phuoc T. Tran (14899412), Sarah Harris-Bookman (14997530), Christopher M. Jackson (14995439), Tomas Garzon-Muvdi (168470), Mira A. Patel (1774930), Xiaobu Ye (596796), Debebe Theodros (14935094), Ann Liu (1353414), Michael Lim (596800), Eric W. Sankey (10143086), Drew M. Pardoll (8689350), Allison M. Martin (14997536), Betty M. Tyler (14997539), Henry Brem (596798), Janis M. Taube (6178604), Peter C. Burger (14997542), Mary Sheu (14997533), Esteban Velarde (418965), Antonella Mangraviti (1353426), Ada Tam (6323708), Dimitrios Mathios (596791), Jennifer E. Kim (14997524), Charles G. Drake (7549529)   +25 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

DataSheet_1_Early detection of soluble CD27, BTLA, and TIM-3 predicts the development of nosocomial infection in pediatric burn patients.docx

, 2022
Thermal injury induces concurrent inflammatory and immune dysfunction, which is associated with adverse clinical outcomes. However, these effects in the pediatric population are less studied and there is no standard method to identify those at risk for ...
Mark Hall (324019), Renata Fabia (13151721), Julia A. Penatzer (13151706), Amber Wolfe (13151715), Josey Hensley (11510572), Robin Alexander (13151709), Rajan K. Thakkar (13151724), Shan Simon (13151712), Julie Breuer (13151718)   +8 more
core   +1 more source

Immune checkpoint changes correlate with the progression and prognosis of amyotrophic lateral sclerosis

Annals of Medicine
Background Amyotrophic lateral sclerosis (ALS) urgently requires robust biomarkers for early diagnosis and prognostic stratification. This study aims to investigate the diagnostic and prognostic potential of membrane-bound and soluble immune checkpoint ...
Sheng Chen, Chunzuan Xu, Changyun Liu, Jiaqi Li, Shupei Ke, Yingqian Lu, Yali Huang, Jialin Chen, Feifei Lin, Huapin Huang, Zhangyu Zou   +10 more
doaj   +1 more source