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Anti-PD-1 Treatment Restores Effector Function in Exhausted-like T Cells from Malignant Ascites of Ovarian Cancer Patients. [PDF]
Cancers (Basel)Almeida-Nunes DL +11 more
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Soluble Tim-3/Gal-9 as predictors of adverse outcomes after kidney transplantation: A cohort study
Clinical Biochemistry, 2022In our previous study, serum soluble T-cell immunoglobulin and mucin structure-3 (sTim-3) and galactosin-9 (sGal-9) were found to be associated with renal function after kidney transplantation. However, it is unclear whether these two indicators can predict adverse outcomes after transplantation.Ninety-one recipients of kidney transplantation were ...
Lanlan Wang, Yi Li, Ya-Mei Li
exaly +3 more sources
Tissue Antigens, 2015
AbstractImmune dysfunction is the main characteristic of sepsis. T cell Ig and mucin domain protein 3 (Tim‐3) on the monocytes has been reported to promote immune homeostasis during sepsis, but the influences of plasm soluble Tim‐3 (sTim‐3) on the immune system during sepsis remain unknown.
F, Ren +10 more
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AbstractImmune dysfunction is the main characteristic of sepsis. T cell Ig and mucin domain protein 3 (Tim‐3) on the monocytes has been reported to promote immune homeostasis during sepsis, but the influences of plasm soluble Tim‐3 (sTim‐3) on the immune system during sepsis remain unknown.
F, Ren +10 more
exaly +3 more sources
International Immunopharmacology, 2018
T cell immunoglobulin mucin-3 (Tim-3) has been reported to participate in the regulation of immune response and the induction of allograft tolerance. However, the association between Tim-3 and renal allograft dysfunction is unclear. We studied the expression of cellular and soluble Tim-3 (sTim-3), soluble galectin-9 (sGal-9) and carcinoembryonic ...
Yun Ying Shi
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T cell immunoglobulin mucin-3 (Tim-3) has been reported to participate in the regulation of immune response and the induction of allograft tolerance. However, the association between Tim-3 and renal allograft dysfunction is unclear. We studied the expression of cellular and soluble Tim-3 (sTim-3), soluble galectin-9 (sGal-9) and carcinoembryonic ...
Yun Ying Shi
exaly +3 more sources
Journal of Leukocyte Biology
Abstract The prognostic significance of soluble immune checkpoint molecule TIM-3 and its ligands in the plasma has been illustrated in various solid tumors, but such study in newly diagnosed acute myeloid leukemia (AML) remains absent.
Qian Jiang +2 more
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Abstract The prognostic significance of soluble immune checkpoint molecule TIM-3 and its ligands in the plasma has been illustrated in various solid tumors, but such study in newly diagnosed acute myeloid leukemia (AML) remains absent.
Qian Jiang +2 more
exaly +3 more sources
Human Immunology
Preeclampsia (PE) is characterized by immune dysfunction, including altered expression levels of multiple immune checkpoints (ICs), which are essential for inducing immune tolerance during pregnancy. While the pivotal role of ICs in PE is well-established, a limited understanding remains of the changes in their various forms, particularly in their ...
Leili Aghebati-Maleki +2 more
exaly +3 more sources
Preeclampsia (PE) is characterized by immune dysfunction, including altered expression levels of multiple immune checkpoints (ICs), which are essential for inducing immune tolerance during pregnancy. While the pivotal role of ICs in PE is well-established, a limited understanding remains of the changes in their various forms, particularly in their ...
Leili Aghebati-Maleki +2 more
exaly +3 more sources
Immune Checkpoint Profiling in Humanized Breast Cancer Mice Revealed Cell-Specific LAG-3/PD-1/TIM-3 Co-Expression and Elevated PD-1/TIM-3 Secretion [PDF]
Cancers, 2023 Checkpoint blockade is particularly based on PD-1/PD-L1-inhibiting antibodies. However, an efficient immunological tumor defense can be blocked not only by PD-(L)1 but also by the presence of additional immune checkpoint molecules.
Gero Brockhoff +2 more
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The Diagnostic Value of Soluble TIM-3 in Oral Squamous Cell Carcinoma
Future Oncology, 2022Objective: To evaluate the soluble TIM-3 (sTIM-3) expression level in oral squamous cell carcinoma (OSCC) and determine its clinical diagnostic potential. Methods: The sTIM-3 and squamous cell carcinoma antigen (SCCAg) levels of 199 OSCC patients and 107 healthy individuals were assessed using an enzyme-linked immunosorbent assay and their individual ...
Kairui Lu +4 more
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Alcohol, 2022
The involvement of immune checkpoint regulators (ICs) in alcohol-associated liver diseases (ALDs) is still largely unknown. Here, we analyzed the levels of 16 soluble ICs (sICs) in male patients with ALD to determine their clinical significance. The 16 sICs were measured using a luminex-based multiplex assay in 115 patients with ALD and 47 healthy ...
Ailyn Fadriquela +4 more
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The involvement of immune checkpoint regulators (ICs) in alcohol-associated liver diseases (ALDs) is still largely unknown. Here, we analyzed the levels of 16 soluble ICs (sICs) in male patients with ALD to determine their clinical significance. The 16 sICs were measured using a luminex-based multiplex assay in 115 patients with ALD and 47 healthy ...
Ailyn Fadriquela +4 more
openaire +2 more sources
Characterization of human soluble Tim-3 and its role in HIV infection (VIR1P.1002)
The Journal of Immunology, 2014Abstract Chronic Human Immunodeficiency Virus Type-1 (HIV) infection results in a loss of HIV-specific CD8+ T cell effector function, termed “exhaustion”, which is mediated, in-part, by the co-inhibitory receptor T-cell immunoglobulin mucin domain-containing protein 3 (Tim-3). Like many other receptors, a soluble form of this protein has
Kiera Clayton +6 more
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