Results 111 to 120 of about 41,164 (267)

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy [PDF]

, 2015
Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor.
Fernández-Medarde, Alberto, Pérez-Herrero, Edgar   +1 more
core   +1 more source

Iron deficiency with and without anemia in pregnancy: A scoping review of prevalence and perinatal impact

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background The prevalence of iron deficiency with anemia and iron deficiency without anemia (IDWA) during pregnancy have not been summarized, and evidence of the direct association of IDWA with adverse perinatal outcomes (APO) are unknown.
Lucky O. Lawani, David M. Naimark, Joel G. Ray, Jessica Widdifield, Paul Eze, Chidumebi J. Idemili, Nadine Shehata   +6 more
wiley   +1 more source

Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines [PDF]

, 2012
Background Fas expression and Fas-induced apoptosis are mechanisms attributed to the selective destruction of cells of the corpus luteum (CL) during luteal regression.
Birt, Alyssa, Duncan, Alice, Forcina, Jennifer, Townson, David H.   +3 more
core   +2 more sources

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Prevalence of micronutrient deficiencies across diverse environments in rural Madagascar

Frontiers in Nutrition
It is estimated that billions of people around the world are affected by micronutrient deficiencies. Madagascar is considered to be particularly nutritionally vulnerable, with nearly half of the population stunted, and parts of the country facing ...
Christopher D. Golden, Christopher D. Golden, Christopher D. Golden, Jessica Zamborain-Mason, Alexander Levis, Benjamin L. Rice, Benjamin L. Rice, Lindsay H. Allen, Daniela Hampel, Daniela Hampel, James Hazen, C. Jessica E. Metcalf, Hervet J. Randriamady, Hervet J. Randriamady, Setareh Shahab-Ferdows, Stephanie M. Wu, Sebastien Haneuse   +16 more
doaj   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Retrograde trafficking of β-dystroglycan from the plasma membrane to the nucleus [PDF]

, 2017
β-Dystroglycan (β-DG) is a transmembrane protein with critical roles in cell adhesion, cytoskeleton remodeling and nuclear architecture. This functional diversity is attributed to the ability of β-DG to target to, and conform specific protein assemblies ...
A Chaumet, A Vasquez-Limeta, B Antonny, B Lara-Chacon, B Tsai, CJ Moore, D Leonoudakis, DK Giri, DK Lee, EH Schroeter, F Rivier, F Sotgia, G Carpenter, G Mathew, G Miller, HJ Liao, HJ Spence, HJ Spence, HW Lo, I Guillemin, I Okamoto, IA Martinez-Vieyra, IA Prudovsky, IG Mills, JL Ilsley, JM Ervasti, JM Myers, KH Holt, L Fuentes-Mera, L Lipscomb, M Durbeej, M James, M Savard, MD Henry, MK Stachowiak, ML Oppizzi, NV Korotkevych, O Ibraghimov-Beskrovnaya, O Thompson, O Thompson, PA Maher, R Gonzalez-Ramirez, S Kidd, SY Lin, YJ Chen, YN Wang, YN Wang   +46 more
core   +4 more sources

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

A review of studies on vascular dementia and iron metabolism

Science Progress
Vascular dementia (VaD) is recognized as the second most prevalent form of dementia after Alzheimer's disease, with its pathogenesis intricately associated with cerebrovascular pathologies, including chronic hypoperfusion, oxidative stress, and ...
Jing Yang, Haoran Zhao, Ying Huang
doaj   +1 more source

Three-dimensional Migration of Neurites Is Mediated by Adhesion Site Density and Affinity [PDF]

, 2000
Three-dimensional neurite outgrowth rates within fibrin matrices that contained variable amounts of RGD peptides were shown to depend on adhesion site density and affinity. Bi-domain peptides with a factor XIIIa substrate in one domain and a RGD sequence
Hubbell, Jeffrey A., Schense, Jason C.
core