Results 71 to 80 of about 1,856,875 (191)

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Urokinase Plasminogen Activator

, 2016
The urokinase plasminogen activator system (uPAS) is an essential mechanism in a wide variety of biological processes such as fibrinoloysis, inflammation, atherosclerotic plaque formation, matrix remodeling during wound healing, tumor invasion ...
Ali Salajegheh, Salajegheh, Ali
core   +1 more source

Seminal Biomarkers and Sperm Proteomic Signatures Differentiate Acute and Chronic Male Accessory Gland Inflammation

Andrology, EarlyView.
ABSTRACT Background Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)‐defined MAGI phenotypes correspond to distinct biological profiles remains insufficiently characterized ...
Emanuela Teveroni, Fiorella Di Nicuolo, Giorgia Mazzuccato, Alessandro Oliva, Emanuele Pierpaolo Vodola, Francesca Mancini, Carla Di Nardo, Edoardo Vergani, Michela Cicchinelli, Federica Iavarone, Cassandra Serantoni, Giuseppe Maulucci, Alessia Riente, Alfredo Pontecorvi, Andrea Urbani, Domenico Milardi, Silvia Baroni   +16 more
wiley   +1 more source

Abstract 17717: Association of Depression with Soluble Urokinase- Type Plasminogen Activator Receptor and Other Markers of Inflammation and Immunity

, 2012
Background: Depression, coronary artery disease (CAD), and inflammation may share pathophysiological links. Soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker of inflammat..
Al Kassem, Hatem, Ghasemzadeh, Nima, Vaccarino, Viola, Manocha, Pankaj, Kumar, Saket, Shah, Amit J., Thorball, Christian W., Sher, Salman, Hammadah, Muhammad, Garcia-Bengochea, Youssef O, Niaz, Adil, Patel, Riyaz S., Syed, Hamid, Veledar, Emir, Tahhan, Ayman Samman, Eapen, Danny J., Kelli, Heval M., Farook, Naureen, Le, Ngoc-Anh, Pimple, Pratik, Nanjundappa, Ravi, Obideen, Malik, Quyyumi, Arshed A., Kabani, Sarah S, Raison, Charles L, Zafari, Rostam, Sperling, Laurence S., Pielak, Tomasz   +27 more
core   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Soluble Urokinase Plasminogen Activator Receptor is Associated With Inflammation in the Vulnerable Human Atherosclerotic Plaque

, 2012
Recently, plasma soluble urokinase plasminogen activator receptor (suPAR) has gained interest as a marker of cardiovascular risk. suPAR is released through the cleavage of urokinase plasminogen activator receptor (uPAR), which is found in monocytes ...
Grönberg, Caitriona,, Persson, Margaretha,, Edsfeldt, Andreas,, Nitulescu, Mihaela,, Nilsson, Marie MN,, Björkbacka, Harry,, Grufman, Helena,, Persson, Ana,, Goncalves, Isabel,, Lund University.   +9 more
core   +2 more sources

Soluble urokinase plasminogen activator receptor: a novel biomarker of pediatric community-acquired and hospitalacquired pneumonia

The Turkish Journal of Pediatrics, 2022
Background. Soluble urokinase plasminogen activator receptor (suPAR) is an emerging biomarker in different clinical disorders but data in pediatric pneumonia is scarce.
Muhammad Said El-Mekkawy, Shimaa El-Shafey Soliman, Nagwan Yossery Saleh   +2 more
doaj   +1 more source

Association between serum soluble urokinase-type plasminogen activator receptor and atrial fibrillation

Journal of Arrhythmia, 2017
Background: Circulating soluble urokinase-type plasminogen activator receptor (suPAR), which can reflect immune activation and low-grade inflammation, may be a novel biomarker of cardiovascular disease.
Noboru Ichihara, Masatoshi Miyamura, Daichi Maeda, Tomohiro Fujisaka, Shu-ichi Fujita, Hideaki Morita, Yoshihiro Takeda, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka   +10 more
doaj   +1 more source

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1289-1297, December 2026.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention

Archives of Medical Science, 2018
Introduction Soluble urokinase plasminogen activator receptor (suPAR) level reflects the general condition of the organism and was proved to give independent information in risk stratification of patients.
Rafał N. Wlazeł, Marta Migała, Marzenna Zielińska, Lucjan Pawlicki, Kinga Rośniak-Bąk, Iwona Szadkowska   +5 more
doaj   +1 more source