Results 81 to 90 of about 1,856,875 (191)

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Soluble urokinase plasminogen activator receptor in vaginally collected amniotic fluid predicting fetal inflammatory response syndrome: a prospective cohort study. [PDF]

BMC Pregnancy Childbirth
Improving noninvasive antenatal diagnosis of fetal inflammatory response syndrome (FIRS) can assist in the evaluation of prenatal risk and reduce perinatal outcomes.
Gulbiniene V, Dumalakiene I, Balciuniene G, Pilypiene I, Narkeviciute I, Novickij V, Vysniauskis G, Ramasauskaite D.   +7 more
europepmc   +3 more sources

Molecular mechanism of Xanthotoxol against gastric cancer: A comprehensive study integrating network pharmacology, computer simulations, and experimental validation

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 2044-2062, October 2026.
Our study systematically explored the anti‐gastric cancer (GC) mechanism of Xanthotoxol (Xan), a natural active phytochemical, using an integrated strategy of network pharmacology, molecular simulation, and experimental validation. First, we identified 39 hub genes associated with gastric cancer using weighted gene co‐expression network analysis (WGCNA)
Yi Yang, Yu‐Hua Du, Chuang Song, Lan‐Nv Ma, Lin Luo, De‐Xu Xu, Xiao‐Yan Ma, Zi‐Ying Zhou, Yi Nan, Yi Yang, Ling Yuan   +10 more
wiley   +1 more source

Serum soluble urokinase plasminogen activator receptor (suPAR) in adults with growth hormone deficiency

Endocrine Connections, 2019
Growth hormone deficiency (GHD) syndrome is associated with adverse levels of several risk factors for cardiovascular diseases (CVD), including metabolic inflammation. However, the impact of GHD and GH treatment on low-grade inflammation is unknown.
Charlotte Höybye, Laia Faseh, Christos Himonakos, Tomasz Pielak, Jesper Eugen-Olsen   +4 more
doaj   +1 more source

Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review

Egyptian Pediatric Association Gazette, 2022
Background Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease that responds poorly to treatment, with a large proportion of patients progressing to end-stage renal disease in spite of initial aggressive treatment.
Phuong Anh Le Thy, Thuy Yen Hoang Thi, Kiem Hao Tran, Huu Son Nguyen   +3 more
doaj   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Predictive value of soluble urokinase plasminogen activator receptor, soluble ST2, and IL-33 in bronchopulmonary dysplasia

, 2014
BACKGROUND: Bronchopulmonary dysplasia (BPD) remains an important complication of preterm births. The soluble form of ST2 (sST2), interleukin-33 (IL-33), and soluble form of the urokinase plasminogen activator receptor (suPAR) have attracted increasing ...
Yaman, Halil, Saldir, Mehmet, Coban, Asuman, Sukran Yildirim, Zeynep Ince, Mehmet Saldir, Ince, Zeynep, Tunc, Turan, Ozgul Bulut, Cekmez, Ferhat, Gokhan Aydemir, Asuman Coban, Yildirim, Sukran, Halil Yaman, Turan Tunc, Ferhat Cekmez, Aydemir, Gokhan, Bulut, Ozgul   +17 more
core   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Relationship Between Soluble Urokinase Plasminogen Activator Receptor (suPAR) and Disease Outcome in Adult-Onset Asthma

Journal of Asthma and Allergy, 2022
Taito Niemelä,1 Hannu Kankaanranta,1– 3 Iida Vähätalo,2 Juho Loponen,1,2 Leena E Tuomisto,2 Onni Niemelä,1,4 Mari Hämäläinen,5 Eeva Moilanen,5 Pinja Ilmarinen1,2 1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland ...
Niemelä T, Kankaanranta H, Vähätalo I, Loponen J, Tuomisto LE, Niemelä O, Hämäläinen M, Moilanen E, Ilmarinen P   +8 more
doaj  

Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis

The Journal of Clinical Investigation, 2022
People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly associated with ...
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope Blakely, Ayse Bilge Ozel, Sarah Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekmulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thørner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Søren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, on behalf of the DBDS Consortium, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, on behalf of the Regeneron Genetics Center, Gunnar Engström, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek   +43 more
doaj   +1 more source