Results 71 to 80 of about 257,838 (267)

Growth of Large Hematin Crystals in Biomimetic Solutions

Crystal Growth & Design, 2014
Hematin crystallization is an essential component of the physiology of malaria parasites. Several antimalarial drugs are believed to inhibit crystallization and expose the parasites to toxic soluble hematin. Hence, understanding the mechanisms of hematin crystal growth and inhibition is crucial for the design of new drugs.
Olafson, Katy N., Rimer, Jeffrey D., Vekilov, Peter G.   +2 more
openaire   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Der Einfluss des Lösungsmittels auf die Kristallwachstumskinetik

CHIMIA, 1978
This review is based upon the results of recent research, which has clarified the role played by the solvent in determining the mechanism and the kinetics of crystal growth from solution.
J.R. Bourne
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Crystal Growth of High-Quality Protein Crystals under the Presence of an Alternant Electric Field in Pulse-Wave Mode, and a Strong Magnetic Field with Radio Frequency Pulses Characterized by X-ray Diffraction

Crystals, 2017
The first part of this research was devoted to investigating the effect of alternate current (AC) using four different types of wave modes (pulse-wave) at 2 Hz on the crystal growth of lysozyme in solution.
Adela Rodríguez-Romero, Nuria Esturau-Escofet, Carina Pareja-Rivera, Abel Moreno   +3 more
doaj   +1 more source

Problematic Crystal Growth – A Microfluidic Solution

, 2019
This project aim was to develop a method to increase the likelihood of a crystalline product, in systems which are often difficult to crystallise. Eight organic acids were chosen for this study, citric, tartaric, malonic, mandelic, oxalic, glutamic, adipic and salicylic acids.
openaire   +2 more sources

Crystal growth in gelled solution: applications to coordination polymers

CrystEngComm, 2016
Some critical issues concerning the complex synthesis and crystallization of designed coordination polymers are highlighted by using gels as diffusion media. The systematic use of gel methods in a variety of different crystallization configurations has been proven useful in revealing the field of existence and the stability hierarchy of competitive and
S. Rizzato, M. Moret, M. Merlini, A. Albinati, F. Beghi   +4 more
openaire   +3 more sources

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source