Results 41 to 50 of about 3,712,265 (295)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Complement to thermodynamics of dyonic Taub-NUT-AdS spacetime
Journal of High Energy Physics, 2021 We examine the thermodynamics of Euclidean dyonic Taub-Nut/Bolt-AdS4 black holes for a variety of horizon geometries to understand how gauge field regularity conditions influence the thermodynamic relations.
Robert B. Mann +2 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Thermodynamic Insights into Isoniazid Solubility in PEG 300 + Water Mixtures
LiquidsSolubility studies are essential for developing more efficient dosing processes and systems. The solubility of INH in a mixture of PEG 300 (1) + water (2) was evaluated at various temperatures using UV/Vis spectrophotometry and the shaking flask method ...
Pedro Nel Martinez Romero +4 more
doaj +1 more source
A model to predict the recovery of cobalt and copper from liquid magnesium distillation
Materials Letters: X, 2022 A model to depict that it is possible to separate solid cobalt and copper from liquid Mg-Co-Cu mixtures is presented. The model aims to demonstrate how the application of solution thermodynamics concepts can help in depicting real processes.
Gabriel Plascencia
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Future Perspectives of Finite-Time Thermodynamics
, 2022 Finite-time thermodynamics was created 45 years ago as a slight modification of classical thermodynamics, by adding the constraint that the process in question goes to completion within a finite length of time [...
Salamon, Peter +3 more
core +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
工程科学学报, 2017 To investigate the laws relating to the mole fraction of a component in a binary solution and its vapor pressure, the entropies of dissolution from the solid phase to the liquid phase of 48 typical compounds were assessed and the compounds were confirmed
GUO Han-jie
doaj +1 more source