Results 191 to 200 of about 5,074,785 (231)

Rehabilitation Wearable Boots and Offloading Methods for Diabetic Foot Ulcer Treatment: A Systematic Review. [PDF]

Int Wound J
Sabzehmeidani Y, Popa AA.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Computer-Aided Solvent Selection for the Design of Integrated Synthesis, Crystallization, and Isolation Processes. [PDF]

Org Process Res Dev
Muhieddine MH, Jonuzaj S, Watson O, Ottoboni S, Sefcik J, Price CJ, Viswanath SK, Armstrong A, Galindo A, Jackson G, Adjiman CS.   +10 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Identifying barriers and potential solutions to improve equitable access to community eye services in central Kenya: a rapid exploratory sequential mixed methods study. [PDF]

BMJ Public Health
Allen LN, Karanja S, Gichangi M, Bunywera C, Muturi E, Gachobi D, Kathure P, Muasa EM, Mutwiri L, Kajuju L, Kagwiria F, Ntabathia B, Rono H, Macleod D, Kim M, Tlhajoane M, Burton MJ, Ramke J, Bolster NM, Bastawrous A.   +19 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Strengthening undergraduate dental public health education in Iran: insights from national symposia. [PDF]

BMC Med Educ
Varmazyari S, Eshrati M, Hessari H, Khami MR.   +3 more
europepmc   +1 more source

Dehumanizing Problems Recognized by Front Line Healthcare Workers and Proposed Low-Cost Solutions to Improve Care. [PDF]

J Patient Exp
Abshire Saylor M, Beach MC, Wright SM.
europepmc   +1 more source