Towards routine structure solution using precession electron diffraction [PDF]
Paul A. Midgley, Alexander S. Eggeman
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Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Decomposition Kinetics of Solution and Lyophilized Powder of S-Nitroso-N-Cetylcysteine. [PDF]
Andrade BF +6 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Influence of Branching Degree and Temperature on the Relaxation of Semidilute and Concentrated Aqueous Solutions of Pectins Obtained from Red- and Blackcurrant. [PDF]
Pancerz M, Ptaszek A.
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Preparation of Fe-Co Alloy Nanoparticles by the Reduction of Aluminum Powders in a Mixed Sulfate Solution [PDF]
Zhang Ting-Ting +3 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Applying Community Engagement Methods to Facilitate Global Co‑Learning among Indigenous Communities. [PDF]
Shin S +12 more
europepmc +1 more source

