Results 151 to 160 of about 23,096 (258)

Acyclicity of improvements in finite game forms [PDF]

Game forms are studied where the acyclicity, in a stronger or weaker sense, of (coalition or individual) improvements is ensured in all derivative games. In every game form generated by an ``ordered voting'' procedure, individual improvements converge to
Kukushkin, Nikolai S.
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A topological characterization of stabilizing consensus. [PDF]

Distrib Comput
Schmid U, Felber S, Rincon Galeana H.
europepmc   +1 more source

Call-by-value Solvability

, 1999
The notion of solvability in the call-by-value -calculus is defined and completely characterized, both from an operational and a logical point of view.
Della Rocca, Simona Ronchi, Luca Paolini, Luca Paolini Universit   +3 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Sensor-Informed Motion-Continuity Control of Shared-Return Electro-Hydraulic Actuator Networks Under Neighboring-Branch Disturbances. [PDF]

Sensors (Basel)
Wu T, Zhao L, Lin G, Gong S.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

GMTW-Ro: a deterministic benchmark for evaluating large language models on grounded Romanian tasks. [PDF]

Front Artif Intell
Bulzan AŞ, Morariu B, Joldea AR, Cernăzanu-Glăvan D, Cernăzanu-Glăvan C.   +4 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Orlicz-Sobolev inequalities and the Dirichlet problem for infinitely degenerate elliptic operators

Electronic Journal of Differential Equations, 2021
Usman Hafeez, Theo Lavier, Lucas Williams, Lyudmila Korobenko   +3 more
doaj