Results 151 to 160 of about 18,240 (305)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A Direct Approach to Viewing Graph Solvability
The viewing graph is a useful way to represent uncalibrated cameras and their geometric relationships: nodes correspond to cameras and edges represent fundamental matrices. By analyzing this graph, it is possible to establish if the problem is “solvable”
Pajdla, Tomas +5 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
SCORING RULE VOTING GAMES AND DOMINANCE SOLVABILITY [PDF]
This paper studies the dominance-solvability (by iterated deletion of weakly dominated strategies) of general scoring rule voting games. The scoring rules we study include Plurality rule, Approval voting, Negative Plurality Rule, Borda rule and Relative ...
Dhillon, Amrita, Buenrostro, Lucia
core
The Solvability Factors of Volume Crime
This research examines the solvability factors of volume crime. It draws from a dataset of 836,616 robberies, violent crimes, sexual crimes, vehicle crimes and residential burglaries from the Metropolitan Police Service (MPS) area in London, England over
core +1 more source
Blow-up of solutions to systems of nonlinear inequalities with singularities on unbounded sets
Electronic Journal of Differential Equations, 2014 We establish conditions for the blow-up of solutions to several systems of nonlinear differential inequalities, with singularities on unbounded sets.
Evgeny Galakhov +2 more
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source