Results 121 to 130 of about 8,796 (305)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Efficient Preparation of Solvable Anyons with Adaptive Quantum Circuits
Physical Review XThe classification of topological phases of matter is a fundamental challenge in quantum many-body physics, with applications to quantum technology. Recently, this classification has been extended to the setting of adaptive finite-depth local unitary ...
Yuanjie Ren +2 more
doaj +1 more source
A Non-Residually Solvable Hyperlinear One-Relator Group
, 2020 . In this short note, we prove that the group ha; bja = [a; a b ]i is hyperlinear.
Jon P Bannon
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Solvable Group Isomorphism Is (Almost) in NP ∩ coNP
, 2011 The Group Isomorphism problem consists in deciding whether two input groups G 1 and G 2 given by their multiplication tables are isomorphic.
Vikraman Arvind, Jacobo Torán
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Solvable model in renormalization group analysis for effective eddy viscosity
, 2003 A solvable model in renormalization group analysis for effective eddy viscosity was presented. A limiting operation of renormalization group analysis yielded an inhomogeneous ordinary differential equation for the invariant effective eddy viscosity.
Lin, B-S, Wang, C-T, Chang, CC
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Subgroups of finitely presented solvable linear groups
, 1977 Let G be a finitely generated solvable linear group. It is shown that there exists a finitely presented solvable linear group H with G embedded in H.
Michael W. Thomson
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source