Results 51 to 60 of about 4,193,000 (282)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2016
Hydrophobic dipeptides with either l-Leu or l-Phe constitute a rather heterogeneous group of crystal structures. Some form materials with large water-filled channels, but there is also a pronounced tendency to incorporate organic solvent molecules, which
Carl Henrik Görbitz
doaj   +1 more source

Rationalization of the formation and stability of bosutinib solvated forms

CrystEngComm, 2016
Crystallization of bosutinib from a wide variety of solvents resulted in many distinct structures, and displayed difficulties to crystallize without solvent incorporation. We have prepared 23 solvated/hydrated and one anhydrous solid form and for 11 of them solved the crystal structures.
Eszter Tieger, Violetta Kiss, György Pokol, Zoltán Finta, Jan Rohlíček, Eliška Skořepová, Michal Dušek   +6 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Conformational Screening of Arbidol Solvates: Investigation via 2D NOESY

Pharmaceutics, 2023
Understanding of the nucleation process’s fundamental principles in saturated solutions is an urgent task. To do this task, it is necessary to control the formation of polymorphic forms of biologically active compounds.
Varvara A. Eventova, Konstantin V. Belov, Sergey V. Efimov, Ilya A. Khodov   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Ethyl 5-[(1H-benzoimidazol-2-yl)aminocarbonyl]-4-hydroxy-2-methyl-6-oxo-1-propyl-1,6-dihydropyridine-3-carboxylate–ethanol–methanol (4/2/1)

Acta Crystallographica Section E, 2009
The asymmetric unit of the title compound, 4C20H22N4O5·2C2H6O·CH4O, contains two pyridine-3-carboxylate molecules, one ethanol molecule and one methanol molecule disordered about in a centre of symmetry.
Svetlana V. Shishkina, Oleg V. Shishkin, Igor V. Ukrainets, Andrei A. Tkach, Lina A. Grinevich   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

New Acidic Precursor and Acetone-Based Solvent for Fast Perovskite Processing via Proton-Exchange Reaction with Methylamine

Molecules, 2020
A new solvent system for PbI2 based on HI solution in acetone with a low boiling point is proposed. High solubility of PbI2 is caused by the formation of iodoplumbate complexes, and reaches a concentration of 1.6 M.
Sergey A. Fateev, Ekaterina I. Marchenko, Andrey A. Petrov, Eugene A. Goodilin, Alexey B. Tarasov   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source