Results 71 to 80 of about 4,193,000 (282)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

2-Fluorobenzyl (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)hydrazine-1-carbodithioate dimethyl sulfoxide monosolvate

IUCrData
In the title solvate, C16H11ClFN3OS2·C2H6OS, the C=N bond adopts a Z-configuration facilitating the formation of an intramolecular N—H...O hydrogen bond to the carbonyl O atom in an S(6) loop.
Aidan P. McKay, David B. Cordes, Mohd Abdul Fatah Abdul Manan   +2 more
doaj   +1 more source

The Development of API Manufacturing Processes – Targets and Strategies

CHIMIA, 2006
This article gives an overview on the questions to be asked and the activities to be planned during the development of an API manufacturing process.
Dierk Wieckhusen
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Simulation of a Solvate Ionic Liquid at a Polarisable Electrode with a Constant Potential [PDF]

, 2018
In this article we discuss the nanostructure and calculated the capacitance of a solvate ionic liquid–electrode interfaces, where the electrode has a constant potential, and is thus inherently polarisable. Lithium ions from the lithiumglyme solvate ionic
Samuel W., Coles, Samuel W. Coles (5637870), Vladislav Ivanistsev (5637866), Vladislav, Ivanistsev   +3 more
core   +1 more source

Physicochemical Insight into Coordination Systems Obtained from Copper(II) Bromoacetate and 1,10-Phenanthroline

Molecules, 2020
Two different coordination compounds of copper were synthesized from the same building blocks (1,10-phenanthroline, bromoacetate anions, and copper cations).
Ewelina Krejner, Tomasz Sierański, Marcin Świątkowski, Marta Bogdan, Rafał Kruszyński   +4 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Griseofulvin solvate solid dispersions with synergistic effect against fungal biofilms [PDF]

, 2019
Fungal biofilms are invariably recalcitrant to antifungal drugs and thus can cause recurrent serious infections. The aim of this work was to prepare highly effective form of the antifungal drug griseofulvin using the chloroform solvate embedded into ...
Al-Obaidi, Hisham, Zariwala, M., Kalgudi, Rachith, Kowalczyk, R.M., Kowalczyk, Radoslaw M., Zariwala, Mohammed Gulrez, Al-Obaidi, H., Kalgudi, R.   +7 more
core   +1 more source

Hydrochlorothiazide N,N-dimethylformamide solvate

, 2006
Hydrochlorothiazide forms a 1: 1 solvate with N,N-dimethylformamide (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4benzothiadiazine- 7-sulfonamide-1,1-dioxide dimethylformamide solvate), C7H8ClN3O4S2 (.) C3H7NO.
Florence, A J, Kennedy, A R, Johnston, A
core   +3 more sources

Azido(1,1-diphenylmethanimine-κN)[hydridotris(pyrazolyl-κN2)borato](triphenylphosphine-κP)ruthenium(II) diethyl ether solvate

Acta Crystallographica Section E, 2008
The reaction of [RuCl(C9H10BN6)(C18H15P)2] with benzophenone imine in methanol, in the presence of sodium azide, leads to the formation of the title compound, [Ru(C9H10BN6)(N3)(HN=CPh2)(C18H15P)]·C4H10O, which crystallizes as the diethyl ether ...
Yih-Hsing Lo, Chih-Yung Chen Hsu, Hung-Chun Tong, Ting-Shen Kuo, Chia-Her Lin   +4 more
doaj   +1 more source