Results 71 to 80 of about 5,622 (240)
Hydrogen bonding versus π-interactions: their key competition in sildenafil solvates [PDF]
, 2020 Herein we report the X-ray characterization of four sildenafil solvates where the conformation of the pyrazolo[3,4-d]pyrimidine and phenyl rings depends on the solvent.
Barbas Cañero, Rafael +4 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Analysis of volumetric properties of liquid mixtures: I. method of binary additive quasi-solvates
Вісник Харківського національного університету: Серія xіміяThe method of binary additive quasi-solvates (BAQS) a new approach for analyzing the physicochemical properties of solutions is proposed. Quasi-solvate Qij is a hypothetical two-particle structure in which one particle i is the ‘solute’ and the other ...
Pavel Efimov
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
ChemistryUnderstanding the reactivity and the crystallinity of energetic materials in a solvent is significantly important for their synthesis, purification, and recrystallization.
Yiru Chen +6 more
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Preparation and desolvation of methyl cholate solvates
, 2013 Holskābes metilestera solvātu iegūšana un desolvatācija. Zvaniņa D., darba vadītājs Mg.Chem. Bērziņš A. Bakalaura darbs, 56 lappuses, 28 attēli, 2 tabulas, 40 literatūras avoti, 3 pielikumi. Latviešu valodā.
Zvaniņa, Dace
core
Structural Insights into the Highly Solvating System of Axitinib via Binary and Ternary Solvates
, 2022 Axitinib is a well-known model in crystal engineering, exhibiting a high tendency to form various solvates, and more than 70 kinds of solvates have been reported.
Jiayin Zhang (1850089) +13 more
core +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source