Results 51 to 60 of about 5,087,038 (341)

On the lifetime and one-year views of reserve risk, with application to IFRS 17 and Solvency II risk margins

open access: yesInsurance, Mathematics & Economics, 2019
This paper brings together analytic and simulation-based approaches to reserve risk in general (P&C) insurance, applied to the traditional actuarial view of risk over the lifetime of the liabilities and to the one-year view of Solvency II.
P. D. England   +2 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Legal regulation of insurance companies' solvency in the EU: Solvency II [PDF]

open access: yesMegatrend Revija, 2018
The improvement of science and practice of risk management, the development of the insurance market, an increasing importance of the insurance industry and the introduction of Basel II regulations in the banking industry, have led to the development of ...
Njegomir Vladimir, Petrović Zdravko
doaj  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

System of governance in insurance companies according to directive 'Solvency II' [PDF]

open access: yesStrani pravni život, 2018
The author of this article examines the system of governance in insurance companies according to new regulatory regime 'Directive Solvency II' which entered into force in the European Union on 1 January 2016.
Leković Vuk
doaj  

The Principle of Proportionality: Unraveling the Practical Application of Proportionality in the EU Regulations and the Solvency II Directive for Insurance Undertakings

open access: yesJournal of Risk and Financial Management
Proportionality, pivotal to EU regulations and Solvency II, tailors rules to insurers’ size and complexity. Inconsistent application by supervisory authorities (NSAs) necessitates clarity to prevent undue costs. This study examines the issue via a review
A. Baldacchino, Simon Grima, Kiran Sood
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Quantitative Market Risk Assessment for Insurance Companies

open access: yesФинансы: теория и практика, 2022
The business strategy, the underwriting policy, the investment strategy of insurance companies and some external factors influence their ability to meet liabilities.
E. V. Aldukhova
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

THE IMPACT OF TRANSITION FROM SOLVENCY I TO SOLVENCY II OVER THE PREMIUM RESERVES IN GENERAL INSURANCE [PDF]

open access: yesEconomica, 2020
One of the most important purposes of any insurance company is to be solvable. The technical reserve represents the main part of the obligations of an insurance company, thus the correct evaluation of this item is primordial.
Oleg VEREJAN, Victor CALDARE
doaj  

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