Results 71 to 80 of about 63,347 (333)

Some Comments on QIS3. [PDF]

In this paper we discuss some issues proposed in the Solvency II - QIS3 report. In particular we comment and discuss the \AISAM-ACME study on non-life long tail liabilities; reserve risk and risk margin assessment under Solvency II".
Dhaene, Jan, Goovaerts, Marc, Van Weert, Koen   +2 more
core  

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Solvency II între IFRS 4 şi IFRS 17 [PDF]

Revista de Studii Financiare, 2020
Aplicarea începând din anul 2005 a Standardului de Raportare Financiară 4 – Contracte de asigurare (International Financial Reporting Standard 4-IFRS 4) a adus prin obiectivele sale, îmbunătătiri, clarificări, dar şi cerințe privind prezentările ...
Costin Andrei ISTRATE
doaj  

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Earthquake insurance in Iran: solvency of local insurers in light of current market practices [PDF]

Natural Hazards and Earth System Sciences
Owing to its geographical position within one of the most seismically active zones globally, Iran has experienced numerous historically impactful earthquakes.
M. Ghafory-Ashtiany, H. Motamed
doaj   +1 more source

Is regulating the solvency of banks counter-productive? [PDF]

This paper contains a critique of solvency regulation such as imposed on banks by Basel I and II. It argues that banks seeking to maximize rate of return on risk-adjusted capital (RORAC) aim at an optimal level of solvency because on the one hand ...
Dieter Pfaff, Jochen Kühn, Peter Zweifel   +2 more
core  

Optimal non-life reinsurance under Solvency II Regime [PDF]

, 2015
The optimal reinsurance contract is investigated from the perspective of an insurer who would like to minimise its risk exposure under Solvency II. Under this regulatory framework, the insurer is exposed to the retained risk, reinsurance premium and ...
Asimit, A.V., Chi, Y., Hu, J.
core   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

A Bayesian Internal Model for Reserve Risk: An Extension of the Correlated Chain Ladder

Risks, 2020
The goal of this paper was to exploit the Bayesian approach and MCMC procedures to structure an internal model to quantify the reserve risk of a non-life insurer under Solvency II regulation.
Carnevale Giulio Ercole, Clemente Gian Paolo   +1 more
doaj   +1 more source