Results 71 to 80 of about 4,684,020 (381)
Insurance, Mathematics & Economics, 2018 This paper brings together analytic and simulation-based approaches to reserve risk in general (P&C) insurance, applied to the traditional actuarial view of risk over the lifetime of the liabilities and to the one-year view of Solvency II.
P. England +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
COMPARATIVE STUDY ON MAIN SOLVENCY ASSESSMENT MODELS FOR INSURANCE FIELD [PDF]
Challenges of the Knowledge Society, 2015 During the recent financial crisis of insurance domain, there were imposed new aspects that have to be taken into account concerning the risks management and surveillance activity.
Daniela Nicoleta SAHLIAN
doaj
De rentecurve voor de waardering van langetermijngaranties op de Solvency II-balans [PDF]
MAB, 2014 Vanaf 2016 geldt een nieuw toezichtskader voor verzekeraars opererend binnen de Europese Unie, genaamd Solvency II. In dit toezichtskader staan marktwaarden en risico’s centraal, waardoor meer kapitaal aangehouden moet worden voor risicovolle producten ...
Paul van Ammelrooij
doaj +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Obstacles to implementation of solvency li regime in nonlife insurance companies in Bosnia and Herzegovina [PDF]
, 2014 Aimed at protection of the market and consumers, the control of solvency is very important for insurer's business activities. Regarding the fact that insurer's insolvency causes a chain of problems, the state regulation is needed that forces insurers to ...
Hodzic, Adela +2 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Machine Learning in Least-Squares Monte Carlo Proxy Modeling of Life Insurance Companies
Risks, 2020 Under the Solvency II regime, life insurance companies are asked to derive their solvency capital requirements from the full loss distributions over the coming year.
Anne-Sophie Krah +2 more
doaj +1 more source
Optimales Anlagevermögen von Versicherungsunternehmen [PDF]
, 2014 Versicherungsunternehmen (VU) unterliegen detaillierten regulatorischen Vorschriften und werden in besonderem Maße behördlich beaufsichtigt. Gegenwärtig erfolgt die Einführung einheitlicher europäischer Regulierungsvorschriften im Rahmen des Projekts ...
Kaposty, Florian, Pelster, Matthias
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source