Results 71 to 80 of about 5,087,038 (341)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The problem of legislative regulation of outsourcing in the insurance industry

open access: yesУченые записки Российской академии предпринимательства, 2021
The article is analyzed the Russian and foreign experience of legal regulations of outsourcing in the insurance industry, as well as proposed of recommendations for improvement legislative regulation.
M. A. Fedorov
doaj  

Financial security of insurance сompanies in the light of the Solvency II directive [PDF]

open access: yes, 2012
The article presents the issue of financial security of insurance companies in light of the Solvency II Directive. The question of minimum capital requirements for conducting operational activities by insurance and reinsurance companies was also ...
Kafková, Eva, Pukala, Ryszard
core   +1 more source

The standard formula of Solvency II: a critical discussion

open access: yesEuropean Actuarial Journal, 2020
Establishing a standard formula (SF) for the regulation of European insurance companies is a Herculean task. It has to acknowledge very different business models and national peculiarities.
M. Scherer, G. Stahl
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Optimales Anlagevermögen von Versicherungsunternehmen [PDF]

open access: yes, 2014
Versicherungsunternehmen (VU) unterliegen detaillierten regulatorischen Vorschriften und werden in besonderem Maße behördlich beaufsichtigt. Gegenwärtig erfolgt die Einführung einheitlicher europäischer Regulierungsvorschriften im Rahmen des Projekts ...
Kaposty, Florian, Pelster, Matthias
core  

A Comparative Analysis Of The Effectiveness Of Three Solvency Management Models [PDF]

open access: yes, 2008
The introduction of the Altman’s Z-score model in 1983 and much recently the Enyi’s Relative Solvency Ratio model in 2005 has divergently provided financial analysts with alternative methods of analyzing corporate solvency which hitherto was ...
Enyi , P. E.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

COMPARATIVE STUDY ON MAIN SOLVENCY ASSESSMENT MODELS FOR INSURANCE FIELD [PDF]

open access: yesChallenges of the Knowledge Society, 2015
During the recent financial crisis of insurance domain, there were imposed new aspects that have to be taken into account concerning the risks management and surveillance activity.
Daniela Nicoleta SAHLIAN
doaj  

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