Results 201 to 210 of about 9,903,999 (366)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Deciphering Molecular and Solvent Effects on Aqueous and Organic Solubility through Interpretable Machine Learning Approaches. [PDF]

ACS Omega
Gopichand B, Nair GS, Nair BG, Melethadathil N.   +3 more
europepmc   +1 more source

4-(4-ethylphenyl)-3-(p-tolyl)-1,2,4-thiadiazol-5(4H)-one: Synthesis, X-ray, Hirshfeld surface, Fukui function, spectroscopic analysis, solvent effects of electronic properties, topological assessment, ADME and molecular docking studies

Aslı Eşme, Yeşim S. Kara, Nalan Tekin
openalex   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Solvent Effects on the Photophysical Properties of Unexplored Imidazo[1,2‑<i>a</i>]pyridine Derivatives. [PDF]

ACS Omega
Justino Garcia Praciano VH, Martinho LA, Duarte Ramos Matos G, Gatto CC, Kleber Z Andrade C.   +4 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Solvent effects on the radical scavenging activity of HP-136 benzofuranone: mechanistic and kinetic insights from quantum chemical calculations. [PDF]

RSC Adv
Manh TD, My VT, Ngoc Diep VH, Le Bich Tram T, Van Bay M, Diep TT, Trung NQ, Mechler A, Vo QV.   +8 more
europepmc   +1 more source

Solvent Effects on the Elasticity of Electrospinnable Polymer Solutions. [PDF]

ACS Polym Au, 2022
Ewaldz E, Randrup J, Brettmann B.
europepmc   +1 more source

Photophysics of p-Hydroxyacetophenone and Its Anionic Form: Understanding the Role of Anti-Kasha Behavior and Solvent Effects

Dominik Heger, David Mužík, Marie Garncarzová   +2 more
openalex   +1 more source

Coupling NaDES-Based Polyphenol Extraction and Anaerobic Fermentation in Grape Pomace Biorefineries: Experimental Evidence and Stoichiometric Assessment of Residual Solvent Effects [PDF]

Federico Battısta, Lucia Sportiello, Francesco Valentino, Maurizio Ugliano, Roberta Tolve   +4 more
openalex   +1 more source