Results 141 to 150 of about 44,482 (297)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
, 2016 Nanoparticles have highly size-dependent properties which need to be harnessed for their appropriate use in various applications. One method that has been used to obtain monodisperse nanoparticles involves the initial synthesis of a relatively ...
Pranav S. Vengsarkar (1472500) +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2017 Thermal field-flow fractionation (ThFFF) is applied to the characterization of vinyl polymers such as poly(vinylcyclohexane) (PVCH) in terms of size, molar mass and chemical composition.
Harald Pasch (1895203) +1 more
core +1 more source
Journal of Ionic LiquidsThe separation of lanthanide compounds typically relies on acidic media, complexing agents and multi-stage solvent extraction processes. Here we report an acid-free approach to lanthanide nitrate separation using liquid-liquid countercurrent ...
Martyn J. Earle +5 more
doaj +1 more source
Fractional precipitation and solvent extraction of thorium
, 1983 KTS-1 Th cevherlerinin ve H2SO4 ve HNO3 ile yapılan özütleme çözeltilerinden toryumu kazanmak için, kademeli çöktürme ve solvent ekstraksiyon çalışmaları yapılmıştır. Çöktürmeler, kontrollü pH da NH4OH ile yapılmış ve toryum çökme verimleri bulunmuştur..
Somer, Ş. Nihal +3 more
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source