Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure [PDF]
Journal of NeuroinflammationBackground Acute exposure to soman (GD), an organophosphate nerve agent (OPNA), irreversibly inhibits acetylcholinesterase (AChE), induces seizures, and could be fatal if not treated immediately.
Nyzil Massey +10 more
doaj +4 more sources
Proinflammatory cytokines, oxidative stress, and organ function as biomarkers of soman (GD) chronic neurotoxicity [PDF]
Scientific ReportsOrganophosphate (OP) nerve agents, such as soman (GD), pose great risk to neurological health by inhibiting acetylcholinesterase, leading to seizures, epilepsy, and behavioral deficits.
Nyzil Massey +4 more
doaj +3 more sources
Chromo-Fluorogenic Detection of Soman and Its Simulant by Thiourea-Based Rhodamine Probe [PDF]
Molecules, 2019 Here, we introduced a novel thiourea-based rhodamine compound as a chromo-fluorogenic indicator of nerve agent Soman and its simulant diethyl chlorophosphate (DCP).
Shengsong Li +8 more
doaj +3 more sources
A wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulations. [PDF]
PLoS ONE, 2015 Irreversible inactivation of human acetylcholinesterase (hAChE) by organophosphorous pesticides (OPs) and chemical weapon agents (CWA) has severe morbidity and mortality consequences. We present data from quantum mechanics/molecular mechanics (QM/MM) and
Brian J Bennion +5 more
doaj +4 more sources
(-)-Phenserine attenuates soman-induced neuropathology. [PDF]
PLoS ONE, 2014 Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agents ...
Jun Chen +11 more
doaj +5 more sources
Disease-Modifying Effects of a Glial-targeted Inducible Nitric Oxide Synthase Inhibitor (1400W) in Mixed-sex Cohorts of a Rat Soman (GD) Model of Epilepsy [PDF]
Journal of Neuroinflammation, 2023 Background Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration, and ...
Suraj S. Vasanthi +17 more
openalex +2 more sources
Epilepsia Open, 2023 Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences ...
Meghan Gage +6 more
doaj +2 more sources
A Comparison of the Neuroprotective Efficacy of Pharmacological Pretreatment and Antidotal Treatment in Soman-Poisoned Rats [PDF]
Acta Medica, 2003 1. To study the influence of pharmacological pretreatment (PANPAL or pyridostigmine combined with biperiden) and antidotal treatment (the oxime HI-6 plus atropine) on soman-induced neurotoxicity, male albino rats were poisoned with a lethal dose of soman
Jiří Kassa +2 more
doaj +2 more sources
Inhalation Apparatus for Generating Sarin and Soman Toxic Vapors [PDF]
Acta Medica, 2003 The developed inhalation system is a dynamic and whole-body exposure model designated for generating sarin or soman vapors. It consists of an evaporating apparatus, an inhalation chamber and a carbon filter.
Lucie Ševelová +2 more
doaj +2 more sources
Frontiers in Cellular Neuroscience, 2022 Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate novel
Meghan Gage +10 more
doaj +2 more sources