Results 171 to 180 of about 9,449 (276)

Seizure and Status Epilepticus in Human Organophosphate Poisoning: A Narrative Review. [PDF]

Neurol Int
Magro G, Marsico O, Tosto F, Lobianco C, Rapisarda L, Mastroianni G, Pascarella A.   +6 more
europepmc   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing. [PDF]

Med Mycol Case Rep
Soman R, Mayya S, Doshi R, Singh I, Ganpule S.   +4 more
europepmc   +1 more source

Moderators' perceptions of consistency in Key Stage 2 writing moderation across local authorities

British Educational Research Journal, EarlyView.
Abstract This article explores moderators’ perceptions of the consistency of Key Stage 2 (KS2) writing moderation across Local Authorities (LAs) in England, a process central to securing the reliability and fairness of teacher assessment in a high‐stakes accountability system.
Rebecca Clarkson
wiley   +1 more source

Perampanel as a second-line therapy to midazolam reduces soman-induced status epilepticus and neurodegeneration in rats. [PDF]

Epilepsia Open
Steier HG, Schultz CR, Niquet J, Nguyen DA, Stone MF, Biney AK, de Araujo Furtado M, Wasterlain CG, Lumley LA.   +8 more
europepmc   +1 more source

Theranostic nanoplatform for high‐performance dual‐modal magnetic resonance imaging‐guided therapy of orthotopic hepatocellular carcinoma

BMEMat, EarlyView.
This article introduces a biomimetic Mn‐doped polydopamine nanoplatform (HAMM NPs) coated with cancer cell membranes. It enables targeted hepatocellular carcinoma theranostics via T1/T2 dual‐mode magnetic resonance imaging and tumor microenvironment‐triggered sonodynamic therapy/chemodynamic therapy, achieving potent antitumor efficacy in subcutaneous ...
Jiayin Lin, Wenbo Chen, Xiuqi Hou, Kai Wang, Fan Liu, Ruling Zhang, Zhong Cao, Jian Zheng   +7 more
wiley   +1 more source

Integrative Analysis of Post-Translational Modifications Identifies a PTM-Enriched Regulatory Core in Human Metabolic Enzymes. [PDF]

Metabolites
Varghese S, Soman SP, Ahmed M, John L, Ramesh P, Soman S, Pai VR, Raju R.   +7 more
europepmc   +1 more source

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

Biological Reviews, EarlyView.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief, Sandra Bouwhuis, Anja Globig, Anne Günther, Wouter Courtens   +4 more
wiley   +1 more source

IsoProDB: an integrated map of human protein isoforms for accelerated research. [PDF]

Database (Oxford)
Soman SP, Ummar S, Ahmed M, Shivamurthy PB, Sreelan S, Ramesh P, Nisar M, Subbannayya Y, Raju R.   +8 more
europepmc   +1 more source

Critical Materials Import and Environmental Preferences: Evidence From G20 and N11 Economies

Business Strategy and the Environment, EarlyView.
ABSTRACT Critical materials such as lithium and cobalt are indispensable for achieving the United Nations' Sustainable Development Goals (SDGs), particularly SDG 7 (Affordable and Clean Energy) and SDG 13 (Climate Action). While these materials enable the deployment of low‐carbon technologies, including electric vehicle batteries and renewable energy ...
Asif Saeed, Atif Iqbal, Faisal Saeed Malik   +2 more
wiley   +1 more source