Results 11 to 20 of about 30,348 (310)

(-)-Phenserine attenuates soman-induced neuropathology. [PDF]

PLoS ONE, 2014
Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agents ...
Jun Chen, Hongna Pan, Cynthia Chen, Wei Wu, Kevin Iskandar, Jeffrey He, Tetsade Piermartiri, David M Jacobowitz, Qian-Sheng Yu, John H McDonough, Nigel H Greig, Ann M Marini   +11 more
doaj   +5 more sources

Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats

Epilepsia Open, 2021
Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid ...
Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain   +6 more
doaj   +3 more sources

Dataset of EEG power integral, spontaneous recurrent seizure and behavioral responses following combination drug therapy in soman-exposed rats [PDF]

Data in Brief, 2019
This article investigated the efficacy of the combination of antiepileptic drug therapy in protecting against soman-induced seizure severity, epileptogenesis and performance deficits.
Lucille A. Lumley, Franco Rossetti, Marcio de Araujo Furtado, Brenda Marrero-Rosado, Caroline R. Schultz, Mark K. Schultz, Jerome Niquet, Claude G. Wasterlain   +7 more
doaj   +3 more sources

Soman hydrolysis catalysed by hypochlorite ions [PDF]

E3S Web of Conferences, 2021
Sarin (GB) and soman (GD) are severely toxic nerve agents that react slowly in water, resulting in long-term poisoning of the water and a serious threat to personnel.
Xu Mengxue, Zhang Hongpeng, Zhu Haiyan, Wang Lianyuan, Zhou Chaohua   +4 more
doaj   +3 more sources

Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman-Induced Status Epilepticus in Male Rats. [PDF]

CNS Neurosci Ther
Andrew PM, MacMahon JA, Liu X, Saito NH, Berger KE, Morgan JE, Dhir A, Harvey DJ, McCarren HS, Rogawski MA, Lein PJ.   +10 more
europepmc   +3 more sources

Dr. Krishna Manohar Soman Rema: A Legacy of Innovation, Education, and Compassion in Pediatric Cardiac Surgery. [PDF]

Cureus
Ramanan S, Subramaniam KG, Dharan BS, Kurian VM, Bhende VV.   +4 more
europepmc   +2 more sources

Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus

Epilepsia Open, 2023
Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences ...
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy   +6 more
doaj   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Wei Yue, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
openalex   +2 more sources

A wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulations. [PDF]

PLoS ONE, 2015
Irreversible inactivation of human acetylcholinesterase (hAChE) by organophosphorous pesticides (OPs) and chemical weapon agents (CWA) has severe morbidity and mortality consequences. We present data from quantum mechanics/molecular mechanics (QM/MM) and
Brian J Bennion, Sebnem G Essiz, Edmond Y Lau, Jean-Luc Fattebert, Aiyana Emigh, Felice C Lightstone   +5 more
doaj   +1 more source

Reply to Soman et al [PDF]

Clinical Infectious Diseases, 2013
A reply to Soman R, Gupta N, Shetty A, Rodrigues C. Are prolonged/continuous infusions of β-lactams for all? Clin Infect Dis 2013;57:323.
Steven A R Webb, Steven A R Webb, Charles D. Gomersall, Joshua S. Davis, Joshua S. Davis, John Myburgh, Charudatt Shirwadkar, Joel M. Dulhunty, Joel M. Dulhunty, Jason A. Roberts, Jason A. Roberts, David L. Paterson, David L. Paterson, Glenn M Eastwood, Jeffrey Lipman, Jeffrey Lipman, Rinaldo Bellomo   +16 more
openaire   +4 more sources