Results 271 to 280 of about 30,348 (310)

A method for generating toxic vapors of soman: Toxicity of soman by inhalation in rats

Toxicology and Applied Pharmacology, 1985
A method for administration of highly toxic chemicals by inhalation was developed. The model has three features of special interest: (1) a diffusion cell for producing a constant gas concentration, if necessary for several hours and days, (2) a small rapidly equilibrated inhalation chamber (1100 ml), and (3) complete isolation of the toxic chemicals ...
Sigrun H. Sterri, H.P. Hjermstad, Pål Aas, Frode Fonnum   +3 more
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Pathophysiology of Soman intoxication in primates

Toxicology and Applied Pharmacology, 1986
Adult baboons were monitored during intravenous infusion of Soman (1,2,2-trimethylpropyl ester, phosphonofluoridate). Three groups of animals were studied. Two groups were anesthetized with sodium pentobarbital (initial dose, 20 mg/kg), instrumented for measurement of systemic blood pressure (BP), pulmonary artery pressure, cardiac output (CO), ECG ...
Gilbert G. Berdine, Gilbert G. Berdine, Antonio R Anzueto, Antonio R Anzueto, Curtis D. White, Curtis D. White, Donald A. Johnson, Donald A. Johnson, Chester Gleiser, Chester Gleiser, Gary T. Moore, Gary T. Moore, Waldemar G. Johanson, Waldemar G. Johanson   +13 more
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Distribution of 3H-soman in mice

Archives of Toxicology, 1985
3H-soman (specific activity 10 Ci/mMol), a potent irreversible cholinesterase inhibitor, was administered IV to mice in a dose of one LD-50, which corresponds to 0.25 mCi/mouse. Animals were sacrificed at 5 min, 2 h and 24 h, and whole body autoradiography was performed.
Nissim Oz, Ayala Balan, Shlomo Shapira, Yacov Ashani, Giora Cohen, Tamar Kadar, Itzhak Baranes, Lily Raveh   +7 more
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Absolute configuration of somane

Russian Chemical Bulletin, 1993
PhCH2Ct K2C% Some parameters of the synthesized compounds are given below: b.p./~ (t7, Torr), n/) 20, m.p./~ (for hydrochloride): la, 53--54 (1), 1.4893, 177.5--178.5 (el ref. 1); lb, 85--86 (1), 1.5251, 165--166; 2a, 52--53 (1), 1.4854, 225--226; 2b, 98 (1.5), 1.5242, 162--162.5; 5, 62 (1), 1.4531, 225--226; 6, --, --, 132.5--143; 7, 120 (1), 1.5132,--
K. F. Koehler, H. Zaddach, Ivan I. Chervin, A. D. Kuntsevich, Remir G. Kostyanovsky   +4 more
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Interaction of soman with ?-cyclodextrin*1

Fundamental and Applied Toxicology, 1986
Abstract Of the following neurotoxic agents, pinacolyl methylphosphonofluoridate (soman), isopropyl methylphosphonofluoridate (sarin) and ethyl N,N-dimethylphosphoramidocyanidate (tabun), only soman was inactivated appreciably at pH 7.40 by β-cyclodextrin. The interaction of soman, a mixture of four stereoisomers designated as C(+)P(−), C(−)P(−), C(+)
Simone Saint-Andre, Bernard Desire
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Toxicokinetics of the four stereoisomers of the nerve agent soman in atropinized rats—Influence of a soman simulator

Toxicology and Applied Pharmacology, 1987
The toxicokinetics of the four stereoisomers of C(+/-)P(+/-)-soman were investigated in anesthetized, atropinized, and artificially ventilated rats at iv doses of 6 (495 micrograms/kg) and 3 LD50. By integration of a thermodesorption/cold trap injector into our GLC analysis, the soman stereoisomers could be followed in rat blood down to a minimum ...
Benschop, H.P., Bijleveld, E.C., Jong, L.P.A. de, Wiel, H.J. van der, Helden, H.P.M. van   +4 more
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Cardiomyopathy in Soman and Sarin intoxicated rats

Toxicology Letters, 1987
Rats surviving various single dose of the organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication ...
A.W. Singer, John S. Graham, N.K. Jaax, C.G. McLeod   +3 more
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Developmental toxicity of soman in rats and rabbits

Teratology, 1990
AbstractSoman (GD; phosphonofluoridic acid, methyl‐,1,2,2‐trimethylpropyl ester) is an organophosphate compound with potent anticholinesterase activity. To determine developmental toxicity, soman was administered orally to CD rats on days 6 through 15 of gestation at dose levels of 0, 37.5, 75, 150, or 165 μg/kg/day and to New Zealand White (NZW ...
John F. Young, Jack C. Dacre, James B. LaBorde, Hudson K. Bates   +3 more
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Binding of soman antidotes to acetylcholine receptors

Biochemical Pharmacology, 1987
It has been reported that several bis-quaternary compounds not necessarily having an oxime function can be used to treat soman poisoning in mice. The mechanism for this protection is not clear, but it has been proposed that such compounds may act by blocking muscarinic or nicotinic acetylcholine receptors.
Clarence A. Broomfield, Ignatius J. Dembure, John Cuculis   +2 more
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Neurochemical Mechanisms in Soman-induced Seizures

Journal of Applied Toxicology, 1997
This study examined brain regional neurotransmitter level changes as a function of seizure duration following soman intoxication. Rats, implanted with cortical electrodes and pretreated with HI-6, received a convulsant dose of soman. At selected times after seizure onset the EEG recording electrodes were removed and the animal was killed.
John H. McDonough, Tsung-Ming Shih
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