Results 271 to 280 of about 41,599 (347)

Unraveling ovarian histology: The key morphological aspects that spur the development of the Fossa ovarii in equine

The Anatomical Record, EarlyView.
Abstract The equine ovary exhibits unique structural and developmental features that distinguish it from those of other domestic species, including the presence of an ovulation fossa and an inversion of cortical and medullary layers. This study aimed to investigate the morphostructural development of the equine fetal ovary, with particular emphasis on ...
Laura Ver Goltz, Silvio Pires Gomes, Bruno Cesar Schimming, Fabio Cesar Magioli Abdala, Maria Angélica Miglino, Tais Harumi de Castro Sasahara   +5 more
wiley   +1 more source

Towards Explainable Computational Toxicology: Linking Antitargets to Rodent Acute Toxicity. [PDF]

Pharmaceutics
Nikitin I, Morgunov I, Safronov V, Kalyuzhnaya A, Fedorov M.   +4 more
europepmc   +1 more source

OGFRL1 deficiency causes CRMO via pathological osteoclastogenesis, with therapeutic response to TNF inhibitor

Arthritis &Rheumatology, Accepted Article.
Objectives To verify the pathogenesis of the OGFRL1 loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a CRMO patient and investigate the underlying mechanism. Methods Whole exome sequencing and Sanger sequencing were performed to identify and confirm the variant.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Efficacy of Acoramidis in Wild-Type and Variant Transthyretin Amyloid Cardiomyopathy: Results From ATTRibute-CM and Its Open-Label Extension.

JAMA Cardiol
Alexander KM, Davis MK, Akinboboye O, Berk J, Bhatt K, Cappelli F, Cuddy SAM, Fontana M, Garcia-Pavia P, Gillmore JD, Griffin JM, Grodin JL, Judge DP, Khouri MG, Lam K, Masri A, Maurer MS, Obici L, Ruberg FL, Sarswat N, Shah K, Soman P, Stern L, Wright R, Xiong K, Cao X, Lystig T, Tamby JF, Castaño A, Katz L, Sinha U, Fox JC, Solomon SD, Grogan M.   +33 more
europepmc   +1 more source

Main factors associated with variability in the assessment of the objective response rate. A re‐analysis of the PHEREXA phase 3 clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Local investigators (LIs) overestimate the objective response rate (ORR) in comparison to Blinded Independent Central Reviewers (BICR) in oncology. In this study, we re‐analysed data obtained in the PHEREXA trial (NCT01026142) with the following aims: i) to confirm at the single‐patient level the discrepancy observed by analysing ...
Gennaro Daniele, Tommaso Giovagnoli, Pierluigi Navarra, Cinzia Dello Russo   +3 more
wiley   +1 more source

Cellular phospho-signaling map of the enigmatic serine/threonine kinase MAST2. [PDF]

Biochem Biophys Rep
Fathima I, Mahin A, Priyanka P, Naurah Vattoth N, Nishana A, Perunelly Gopalakrishnan A, Soman S, Raju R.   +7 more
europepmc   +1 more source

Micro/nanorobots for detecting and eliminating biological and chemical warfare agents

BMEMat, EarlyView.
Fuel‐powered and field‐driven micro/nanorobots provide a cutting‐edge platform to safeguard national security and defense. This review reports the latest research progress in micro/nanorobots in sensing and detoxifying biological and chemical warfare agents.
Song Li, Huaijuan Zhou, Di Shi, Zdeněk Sofer, Jinhua Li   +4 more
wiley   +1 more source

Autophagy-driven MHC-I downregulation enables NK cell-mediated clearance of intracellular uropathogenic <i>E. coli</i> in urinary tract infection. [PDF]

Anim Cells Syst (Seoul)
Naskar M, Suk G, Yoon H, Lim D, Abraham SN, Choi HW.   +5 more
europepmc   +1 more source

FDA Approval of ¹⁸F-Flurpiridaz for PET: Stepping into a New Era of Myocardial Perfusion Imaging? [PDF]

J Nucl Med
Schindler TH, Bateman TM, Berman DS, Chareonthaitawee P, De Blanche LE, Dilsizian V, Dorbala S, Gropler RJ, Shaw LL, Soman P, Winchester DE, Verberne HJ, Ahuja S, Beanlands R, Di Carli M, Murthy VL, Ruddy TD, Schwartz RG.   +17 more
europepmc   +1 more source

Revealing site-specific molecular features mediating contacts of heterochromatin protein 1 α (HP1α) and the interactions with chromatin and DNA in LLPS environments. [PDF]

Commun Biol
Zhai Z, Soman A, Kuang J, Guo J, Chen Y, Zhao L, Prasanna C, Putri DA, Glukhov GS, Chng CP, Huang C, Nordenskiöld L, Xue K, Shi X.   +13 more
europepmc   +1 more source