Results 21 to 30 of about 41,599 (347)

Proteomics Reveals Mechanisms of Metabolic Dysregulation in Soman Neurotoxicity [PDF]

Toxics
Soman, an organophosphorus nerve agent, induces neurotoxicity primarily by inhibiting acetylcholinesterase, triggering a series of pathological events including cholinergic crisis, seizures, calcium overload, oxidative stress, mitochondrial dysfunction ...
Xing-Xing Zong, Qian Jin, Tong Shi, Ruihua Zhang, Jingjing Shi, Chen Wang, Liqin Li   +6 more
doaj   +2 more sources

Studying of the complexes product of the nerve agent Soman with the Butyrylcholinesterase and Acetylcholinesterase Enzymes

مجلة بغداد للعلوم, 2008
Cholinesterases are among the most efficient enzymes known. They are divided into two groups: acetylcholinesterase (AChE) involved in the hydrolysis of the neurotransimitter acetylcholine, and butyrylcholinesterase (BChE) of unknown function.
Baghdad Science Journal
doaj   +3 more sources

Ultra-Sensitive Analysis of Organophosphorus Compounds by Comparative GC-FPD and GC-ICP-MS: Implications for Chemical Warfare Agent Detection [PDF]

Molecules
Organophosphorus chemical warfare agents such as sarin (GB), soman (GD), and cyclosarin (GF) rank among the most toxic substances known, making trace-level detection critical for public and military safety.
Michał Wiktorko, Piotr Kot, Anna Puchała, Patrycja Bryczek-Wróbel, Klaudia Izabela Rzadkowska, Barbara Wiaderek   +5 more
doaj   +2 more sources

How Is Acetylcholinesterase Phosphonylated by Soman? An Ab Initio QM/MM Molecular Dynamics Study [PDF]

Journal of Physical Chemistry A, 2014
Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ACh) and terminates synaptic signals by reducing the effective concentration of ACh in the synaptic clefts.
Gulseher Sarah Sirin, Yingkai Zhang
openalex   +2 more sources

A Chromogenic Probe for the Selective Recognition of Sarin and Soman Mimic DFP [PDF]

ChemistryOpen, 2014
The synthesis, characterization and sensing features of a novel probe 1 for the selective chromogenic recognition of diisopropylfluorophosphate (DFP), a sarin and soman mimic, in 99:1 (v/v) water/acetonitrile and in the gas phase is reported.
Sameh El Sayed, Lluı́s Pascual, Alessandro Agostini, Ramón Martínez‐Máñez, Félix Sancenón, Ana M. Costero, Margarita Parra, Salvador Gil   +7 more
openalex   +2 more sources

Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population [PDF]

Journal of Pharmacology and Experimental Therapeutics, 2018
James P. Apland, Vassiliki Aroniadou‐Anderjaska, Taíza H. Figueiredo, Volodymyr I. Pidoplichko, Katia Rossetti, Maria F. M. Braga   +5 more
openalex   +2 more sources

PGC 1α-Mediates Mitochondrial Damage in the Liver by Inhibiting the Mitochondrial Respiratory Chain as a Non-cholinergic Mechanism of Repeated Low-Level Soman Exposure.

Biological and Pharmaceutical Bulletin, 2023
This work aimed to assess whether mitochondrial damage in the liver induced by subacute soman exposure is caused by peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) and whether PGC-1α regulates mitochondrial respiratory chain
Qian Jin, Yi Zhang, Yalan Cui, Meng Shi, Jingjing Shi, Siqing Zhu, T. Shi, Ruihua Zhang, Xuejun Chen, Xingxing Zong, Chen Wang, Liqin Li   +11 more
semanticscholar   +1 more source

Dr. Krishna Manohar Soman Rema: A Legacy of Innovation, Education, and Compassion in Pediatric Cardiac Surgery. [PDF]

Cureus
Ramanan S, Subramaniam KG, Dharan BS, Kurian VM, Bhende VV.   +4 more
europepmc   +3 more sources

Reply to Soman et al [PDF]

Clinical Infectious Diseases, 2013
A reply to Soman R, Gupta N, Shetty A, Rodrigues C. Are prolonged/continuous infusions of β-lactams for all? Clin Infect Dis 2013;57:323.
Dulhunty, Joel M., Roberts, Jason A., Davis, Joshua S., Webb, Steven A. R., Bellomo, Rinaldo, Gomersall, Charles, Shirwadkar, Charudatt, Eastwood, Glenn M., Myburgh, John, Paterson, David L., Lipman, Jeffrey   +10 more
openaire   +3 more sources

Polyclonal Antibody to Soman-Tyrosine [PDF]

Chemical Research in Toxicology, 2013
Soman forms a stable, covalent bond with tyrosine 411 of human albumin, with tyrosines 257 and 593 in human transferrin, and with tyrosine in many other proteins. The pinacolyl group of soman is retained, suggesting that pinacolyl methylphosphonate bound to tyrosine could generate specific antibodies.
Bin, Li, Ellen G, Duysen, Marie-Thérèse, Froment, Patrick, Masson, Florian, Nachon, Wei, Jiang, Lawrence M, Schopfer, Geoffrey M, Thiele, Lynell W, Klassen, John, Cashman, Gareth R, Williams, Oksana, Lockridge   +11 more
openaire   +2 more sources