Results 291 to 300 of about 30,348 (310)
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Toxogonin in Sarin, Soman and Tabun poisoning
Biochemical Pharmacology, 1965The oximes P2S, TMB-4 and Toxogonin have been tested as reactivators of Sarin and Tabun inhibited acetylcholinesterase. The protective effect of the oximes has been studied on atropinized mice in experimental Sarin, Soman and Tabun poisoning. Toxogonin is a better reactivator than P2S and comparable to TMB-4. In the presence of 10 mg/kg atropine (i.p.)
Birgitta Tolagen, Edith Heilbronn
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Toxicology and Applied Pharmacology, 2004
The combined effects of physostigmine and procyclidine (antagonizing muscarinic, nicotinic, and NMDA receptors) were tested against various doses of soman. Physostigmine (0.1 mg/kg) in combination with procyclidine doses of 1, 3, or 6 mg/kg effectively prevented the development of convulsions and hippocampally monitored seizures when the doses of soman
Trond Myhrer +3 more
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The combined effects of physostigmine and procyclidine (antagonizing muscarinic, nicotinic, and NMDA receptors) were tested against various doses of soman. Physostigmine (0.1 mg/kg) in combination with procyclidine doses of 1, 3, or 6 mg/kg effectively prevented the development of convulsions and hippocampally monitored seizures when the doses of soman
Trond Myhrer +3 more
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In vitro Detoxification of Soman in Human Plasma
Toxicological Sciences, 1985The degradation of soman in human plasma and at a physiological pH has been studied at the high nanomolar level. From a comparison between degradation of racemic soman in preincubated and unpreincubated plasma the concentration of phosphonylation sites was estimated at some 120 nM.
Herbert C. De Bisschop +3 more
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Differences in the toxicity of soman in various strains of mice
Fundamental and Applied Toxicology, 1981The acute toxicity of soman was assessed in eight strains of mice (ALAS, CD-1, C57BL, CF1, CFW, C3H, DBA and BALB/c). In fasted animals the LD50 values for soman varied from 98 micrograms/kg in C57BL mice to 151 micrograms/kg in BALB/c mice. In general in non-fasted mice the soman LD50 was not significantly changed except in ALAS strain where the soman
B.T. Hand, J.D. Shiloff, J.G. Clement
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Inactivation of sarin and soman by cyclodextrins in vitro
Experientia, 1987Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for beta-cyclodextrin than for alpha- or gamma-cyclodextrins. Thus beta-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more
B. Désiré, S. Saint-André
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Neurobehavioral toxicology and teratology, 1986
When rats are intoxicated with high doses of the cholinesterase inhibitor soman (5-8 X LD50), the compound is temporarily stored in a "depot" from which it is gradually released. Thus, despite an initially successful therapy with the oxime HI-6 and atropine, the released soman re-intoxicates the organism and death may ensue in several hours.
Wolthuis, O.L. +2 more
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When rats are intoxicated with high doses of the cholinesterase inhibitor soman (5-8 X LD50), the compound is temporarily stored in a "depot" from which it is gradually released. Thus, despite an initially successful therapy with the oxime HI-6 and atropine, the released soman re-intoxicates the organism and death may ensue in several hours.
Wolthuis, O.L. +2 more
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GLC-analysis and Pharmacokinetics of the Four Stereoisomers of Soman
Toxicological Sciences, 1981Chemicals/CAS: soman, 96-64-0; Organophosphorus Compounds; Soman, 96-64 ...
Benschop, H.P. +2 more
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Stereoselective Syntheses of Soman Analog
1993Abstract : The subject of catalytic antibodies has attracted a great deal of attention because of their capability of catalyzing a variety of chemical transformations. These antibodies can be generated against almost any target molecule of interest, however, the design of the hapten is the most critical part.
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Problems in the therapy of soman poisoning
Fundamental and Applied Toxicology, 1981O.L. Wolthuis, E. Meeter, F. Berends
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Enzymatic synthesis of sarin and soman
Biochemical Pharmacology, 1985Ting-Chung Chou, Han Zhang, Man-Chi Sun
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