Results 301 to 310 of about 41,599 (347)

Binding of soman antidotes to acetylcholine receptors

Biochemical Pharmacology, 1987
It has been reported that several bis-quaternary compounds not necessarily having an oxime function can be used to treat soman poisoning in mice. The mechanism for this protection is not clear, but it has been proposed that such compounds may act by blocking muscarinic or nicotinic acetylcholine receptors.
C, Broomfield, I J, Dembure, J, Cuculis
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Studies Using a Monoclonal Antibody against Soman

Toxicological Sciences, 1984
The production of antibodies against the organophosphorus hapten soman has been undertaken in vivo in rabbits and in vitro by employing monoclonal techniques. The polyclonal rabbit antibodies did not cross-react with soman but were inhibited by soman analogs in a competitive inhibition enzyme immunoassay ( CIEIA ).
D E, Lenz, A A, Brimfield, K W, Hunter, H P, Benschop, L P, de Jong, C, van Dijk, T R, Clow   +6 more
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Soman Intoxication and the Blood-Brain Barrier

Toxicological Sciences, 1985
Brain capillaries (microvessels) were isolated from rabbit brain. Morphological characterization revealed relatively pure fractions of microvessels consisting of the capillary endothelium, the basal membrane, and the pericyte. These fractions of brain capillaries show acetylcholinesterase (AChE) and monoamine oxidase (MAO) activity, but lack catechol-O-
A, Sellström, G, Algers, B, Karlsson
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Combination anticonvulsant treatment of soman-induced seizures

Journal of Applied Toxicology, 2001
These studies investigated the effectiveness of combination treatment with a benzodiazepine and an anticholinergic drug against soman-induced seizures. The anticholinergic drugs considered were biperiden, scopolamine, trihexaphenidyl, and procyclidine; the benzodiazepines were diazepam and midazolam.
I, Koplovitz, S, Schulz, M, Shutz, R, Railer, R, Macalalag, M, Schons, J, McDonough   +6 more
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Search for a therapy against soman-intoxication

Neuroscience & Biobehavioral Reviews, 1994
This mini-review mainly describes a part of the pharmacological research carried out in our laboratory during the past decades, aimed at finding a therapy against intoxication by cholinesterase-inhibiting organophosphates, in particular against the nerve agent soman. In particular soman, because this is one of the nerve agents that consistently appears
O L, Wolthuis, H P, van Helden, B P, Melchers, R W, Busker, D M, de Groot   +4 more
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Inhalation Toxicokinetics of Soman Stereoisomers in the Atropinized Guinea Pig with Nose-Only Exposure to Soman Vapor

Toxicology and Applied Pharmacology, 1998
The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman were studied in anesthetized, atropinized guinea pigs for nose-only exposure to soman vapor. During exposure the respiratory minute volume (RMV) and respiratory frequency (RF) were monitored.
Langenberg, J.P., Spruit, W.E.T., Wiel, H.J. van der, Trap, H.C., Helmich, R.B., Bergers, W.W.A., Helden, H.P.M. van, Benschop, H.P.   +7 more
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Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice

Neurotoxicity research, 2021
J. Kassa, J. Karasova
semanticscholar   +1 more source

Toxogonin in Sarin, Soman and Tabun poisoning

Biochemical Pharmacology, 1965
The oximes P2S, TMB-4 and Toxogonin have been tested as reactivators of Sarin and Tabun inhibited acetylcholinesterase. The protective effect of the oximes has been studied on atropinized mice in experimental Sarin, Soman and Tabun poisoning. Toxogonin is a better reactivator than P2S and comparable to TMB-4. In the presence of 10 mg/kg atropine (i.p.)
E, HEILBRONN, B, TOLAGEN
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Ferrocene-carbamate as prophylaxis against soman poisoning

Fundamental and Applied Toxicology, 1984
The effect of a carbamate derivative of ferrocene as a prophylactic agent toward soman poisoning was studied in mice. A sixfold decrease of the acute toxicity (24-hr LD50) of soman was obtained when the carbamate (5.5 mg/kg = 1/30 X LD50) was given intraperitoneally 30 min before soman.
N, Karlsson, R, Larsson, G, Puu
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Residual behavioral incapacitation after therapy of soman intoxication: the effect of a soman simulator.

Neurobehavioral toxicology and teratology, 1986
When rats are intoxicated with high doses of the cholinesterase inhibitor soman (5-8 X LD50), the compound is temporarily stored in a "depot" from which it is gradually released. Thus, despite an initially successful therapy with the oxime HI-6 and atropine, the released soman re-intoxicates the organism and death may ensue in several hours.
Wolthuis, O.L., Vanwersch, R.A.P., Helden, H.P.M. van   +2 more
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