Results 41 to 50 of about 291 (113)
Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source
Artificial lipidation of proteins and peptides: from mechanism to clinical applications
The FEBS Journal, Volume 293, Issue 5, Page 1269-1284, March 2026.Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley +1 more source
European Journal of Endocrinology, 2023 Abstract Objective Investigate efficacy, safety, and tolerability of 3 once-weekly somapacitan doses compared with daily growth hormone (GH) administration in short children born small for gestational age (SGA).
Anders Juul +7 more
openaire +3 more sources
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Drug Testing and Analysis, Volume 17, Issue 8, Page 1417-1442, August 2025.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Escherichia coli in the production of biopharmaceuticals
Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley +1 more source
Clinical Endocrinology, Volume 102, Issue 2, Page 136-146, February 2025.ABSTRACT Objective Children born small for gestational age (SGA) are at increased risk of health issues. This study evaluated the efficacy, safety and optimal dose of PEGylated‐recombinant human growth hormone (PEG‐rhGH) in these children. Design In this multicentre, randomised, open‐label, Phase 2 trial conducted at nine clinical sites in China ...
Xiaoping Luo +17 more
wiley +1 more source
Somapacitan in children with idiopathic short stature: a randomized controlled phase 3 study
European Journal of EndocrinologyAbstract Objective Daily growth hormone (GH) injections restore normal growth and improve psychological outcomes in children with idiopathic short stature (ISS) but treatment burden is significant.
Jennifer Abuzzahab +7 more
openaire +2 more sources
New Insights Into Hepatic Impairment (HI) Trials
Clinical and Translational Science, Volume 18, Issue 1, January 2025.ABSTRACT Hepatic impairment (HI) trials are traditionally part of the clinical pharmacology development to assess the need for dose adaptation in people with impaired metabolic capacity due to their diseased liver. This review aimed at looking into the data from dedicated HI studies, cluster these data into various categories and connect the effect by ...
Sebastian Haertter +4 more
wiley +1 more source
Drug Testing and Analysis, Volume 16, Issue 1, Page 5-29, January 2024.Abstract In this 16th edition of the annual banned‐substance review on analytical approaches in human sports drug testing, literature on recent developments in this particular section of global anti‐doping efforts that was published between October 2022 and September 2023 is summarized and discussed.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source