Results 1 to 10 of about 311 (111)

Two-Year Real-World Experience With Somatrogon in Children and Adolescents With Growth Hormone Deficiency [PDF]

Frontiers in Endocrinology
IntroductionGrowth hormone deficiency (GHD) in children and adolescents is a chronic condition requiring long-term therapy with recombinant human growth hormone (rhGH).
Gianluca Tornese, Gianluca Tamaro, Alice Fachin   +2 more
exaly   +10 more sources

Somatrogon in pediatric growth hormone deficiency: a comprehensive review of clinical trials and real-world considerations [PDF]

Annals of Pediatric Endocrinology & Metabolism
Growth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood.
Aristides K. Maniatis, Michael P. Wajnrajch, Marc Thomas, Sung Beom Chung, Jieun Lee   +4 more
doaj   +6 more sources

Understanding the Burden of Weekly Somatrogon Injections Compared With Daily Somatropin Injections in Children With Growth Hormone Deficiency: A Plain Language Summary of Publication [PDF]

Therapeutic Advances in Endocrinology and Metabolism
• For children with growth hormone deficiency, once-weekly somatrogon injections were less of a burden than once-daily somatropin injections. • The safety of weekly somatrogon was similar to that of daily somatropin .
Aristides K. Maniatis, Mauri Carakushansky, Sonya Galcheva, Gnanagurudasan Prakasam, Larry A. Fox, Adriana Dankovcikova, Jane Loftus, Andrew A. Palladino, Maria de los Angeles Resa, Carrie Turich Taylor, Mehul T. Dattani, Jan Lebl   +11 more
exaly   +4 more sources

Comparing the Efficacy and Safety of Weekly Somatrogon With Daily Somatropin in Asian Children Living With Growth Hormone Deficiency: A Plain Language Summary of Publication [PDF]

Therapeutic Advances in Endocrinology and Metabolism
Summary Key takeaways Children living with growth hormone deficiency (GHD) are usually treated with daily injections of a growth hormone called somatropin to help them grow normally. Somatrogon is a growth hormone treatment that only needs to be injected
Roy Gomez, Vaman Khadilkar, Michael P Wajnrajch   +2 more
exaly   +4 more sources

Pharmacovigilance evaluation of somatrogon-associated adverse events in real-world databases [PDF]

Endocrine Connections
Background: Somatrogon, a long-acting recombinant human growth hormone, is used in children with growth hormone deficiency. While clinical trials have shown its safety, real-world post-marketing data are limited, and uncommon or delayed adverse events ...
Mengyuan Cai, Qian Guo, Huqiang Dong, Yabo Wang, Zhongyu Han, Ping Xu   +5 more
doaj   +5 more sources

Comparing the Efficacy and Safety of Weekly Somatrogon With Daily Somatropin to Treat Children With Growth Hormone Deficiency: A Plain Language Summary of Publication [PDF]

Therapeutic Advances in Endocrinology and Metabolism
• The efficacy of weekly somatrogon injections was no different from that of daily somatropin injections to treat children who don’t make enough growth hormone to grow adequately. ○ Efficacy refers to how well a drug works in a clinical trial. ○ Children
Lawrence A Silverman, Aleksandra Pastrak
exaly   +4 more sources

Cost-Effectiveness of Somatrogon in the Spanish Pediatric Population With Growth Hormone Deficiency [PDF]

Expert Review of Pharmacoeconomics and Outcomes Research, 2023
To analyze the cost-effectiveness of weekly somatrogon compared to daily growth hormones (GH-d) in the pediatric population of Spain with growth hormone deficiency (GHD).Markov model with two states (patients with or without GH-d or somatrogon treatment) in prepubertal children (3 to 11 years and 3 to 12 years in girls and boys, respectively) with GHD ...
D Rubio-Rodríguez, C Rubio-Terrés
exaly   +7 more sources

Efficacy and Safety of Once-Weekly Somatrogon Following Up to 4 Years of Treatment in Japanese Children With Growth Hormone Deficiency: Results From an Open-Label Extension of a Phase 3 Study [PDF]

Endocrine Journal
Somatrogon is a long-acting recombinant human growth hormone approved in several countries, including Japan, for the treatment of children with growth hormone deficiency (GHD).
Akifumi Okayama, Yukihiro Hasegawa, Tohru Yorifuji   +2 more
exaly   +4 more sources

Physician Experience With Once-Weekly Somatrogon Versus Once-Daily rhGH Regimen in Pediatric Patients With Growth Hormone Deficiency: A Cross-Sectional Survey of Physicians From the Global Phase 3 Study

Frontiers in Endocrinology, 2023
IntroductionThe standard of care for pediatric growth hormone deficiency (pGHD) is once-daily recombinant human growth hormone (rhGH). Somatrogon, a long-acting rhGH, requires less frequent, once-weekly, dosing.
Roy Gomez, Mohamad Maghnie, Diane M Turner-Bowker   +2 more
exaly   +3 more sources

Weekly Growth Hormone Somatrogon and Clinical Use Principles

Güncel Pediatri
The recombinant human growth hormone has been used for about 40 years and is administered as a single daily dose. Long-acting growth hormones are developed to enhance therapy adherence and reduce therapy load.
Erdal Eren, Furkan Erdoğan
doaj   +2 more sources