Results 151 to 160 of about 343,748 (316)

709. Gene Correction and Gene Knockouts in Human Somatic Cells Using Zinc Finger Nucleases [PDF]

, 2004

openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Derivation of embryonic stem cells from cloned blastocysts using improved somatic cell nuclear transfer in common marmosets. [PDF]

Stem Cell Reports
Matoba S, Kurotaki Y, Funaya S, Yamada Y, Ogonuki N, Shinohara H, Yamamoto M, Yoneda N, Homma T, Higuchi Y, Sasaki E, Ogura A.   +11 more
europepmc   +1 more source

Exome sequencing identifies somatic point mutations associated with acquired endocrine resistance in breast cancer cell lines [PDF]

, 2012
Natasja Ehlers, Zhu Da, Daniel Eliáš, Xue Lin, Jian Li, Christina Bjerre, Nils Brünner, Lars Bolund, Jun Wang, Ramneek Gupta, Henrik J. Ditzel   +10 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Single-step genome-wide association study of milk somatic cell scores across multi-cattle breeds in Ethiopia. [PDF]

Anim Biotechnol
Chernet TF, Tarekegn GM, Ally OM, Meseret S, Mrode R, Negussie E, Bedada ZE, Gebreyohanes G, Ekine-Dzivenu C, Tera A, Tessema TS.   +10 more
europepmc   +1 more source

Somatic Cell Mutations in Atomic Bomb Survivors [PDF]

, 1991
Mitoshi Akiyama, Nori Nakamura, Masayuki Hakoda, Seishi Kyoizumi, Jun‐ichi Kushiro, Yuko Hirai, Yoichiro Kusunoki   +6 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre- and Post-Implantation Epigenetic Barriers. [PDF]

Adv Sci (Weinh)
Li Y, Sun S, Xu Y, Zhang J, Du Y, Cao Y, Liao Z, Xie Y, Bian X, Huang J, Wang M, Liu Z, Sun Q, Lu F.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source