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Embryonic and somatic cell cloning
Reproduction, Fertility and Development, 1999Revolutionary opportunities in biology, medicine and agriculture arise from the observation that offspring are obtained after nuclear transfer if somatic donor cells are induced to become quiescent. Exploitation of many of these opportunities will depend upon optimizing procedures for nuclear transfer.
I, Wilmut, L, Young, K H, Campbell
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MicroRNAs in somatic cell reprogramming
Current Opinion in Cell Biology, 2013The generation of induced pluripotent stem (iPS) cells by exogenous transcription factors involves a comprehensive rearrangement of cellular functions, including the microRNA profile. The resulting cell lines are similar to embryonic stem (ES) cells and have therefore raised much interest for in vitro studies and the perspective of clinical application.
Xichen, Bao +7 more
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Reprogramming of Somatic Cells to Pluripotency
2010Reprogramming of somatic cells into pluripotent stem cells has been achieved by introducing four transcription factors, Sox2, Oct3/4, Klf4 and c-Myc, in 2006. These induced pluripotent stem (iPS) cells have raised hopes for a new era of regenerative medicine because they can avoid the ethical problems and innate immune rejection associated with ...
Masato, Nakagawa, Shinya, Yamanaka
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Reprogramming of somatic cells: iPS and iN cells.
Progress in brain research, 2017Limited access to human neurons has posed a significant barrier to progress in biological and preclinical studies of the human nervous system. The advent of cell reprogramming technologies has widely disclosed unprecedented opportunities to generate renewable sources of human neural cells for disease modeling, drug discovery, and cell therapeutics ...
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A tribute to somatic cell reprogrammers
MHR: Basic science of reproductive medicine, 2012For many biologists, the ‘holy grail’ has been to derive pluripotent cells that have the potential to differentiate into all cell types of the body. They represent enormous scientific value as they can be used to study differentiation, the onset of disease and, in the long term, offer a significant therapeutic potential (Colman and Dreesen, 2009). Long
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Transformationlike Phenomena in Somatic Cells
1968Publisher Summary This chapter explains how to reproduce transformation phenomena by the action of exogenous DNA on somatic cells have been confronted with a number of difficulties, some of which are hardly foreseen. The additional complications arose in connection with the appearance of transformationlike phenomena in experiments with RNA as the ...
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Construction of Somatic Cell Hybrids
Current Protocols in Human Genetics, 1996AbstractSomatic cell hybridization is the method of choice to separate a chromosome of interest from the full chromosome complement and obtain a permanent source of the chromosome. This unit begins with the choice of fusion techniques and selectable markers for hybrids containing a chromosome of interest.
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