Results 181 to 190 of about 632,458 (305)

Fecal microbiota profiling in organic and conventional dairy farms differing in farm-level somatic cell counts and raw milk bacterial infections. [PDF]

Front Vet Sci
Kim SJ, Ro Y, Lee GS, Kizaki K, Kimura A, Kim YH.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Machine learning-based clinical mastitis detection in dairy cows using milk electrical conductivity and somatic cell count. [PDF]

Front Vet Sci
Pan L, Chen X, Han D, Li N, Chen D, Wang J, Chen J, Huo X.   +7 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre- and Post-Implantation Epigenetic Barriers. [PDF]

Adv Sci (Weinh)
Li Y, Sun S, Xu Y, Zhang J, Du Y, Cao Y, Liao Z, Xie Y, Bian X, Huang J, Wang M, Liu Z, Sun Q, Lu F.   +13 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Single-step genome-wide association study of milk somatic cell scores across multi-cattle breeds in Ethiopia. [PDF]

Anim Biotechnol
Chernet TF, Tarekegn GM, Ally OM, Meseret S, Mrode R, Negussie E, Bedada ZE, Gebreyohanes G, Ekine-Dzivenu C, Tera A, Tessema TS.   +10 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Derivation of embryonic stem cells from cloned blastocysts using improved somatic cell nuclear transfer in common marmosets. [PDF]

Stem Cell Reports
Matoba S, Kurotaki Y, Funaya S, Yamada Y, Ogonuki N, Shinohara H, Yamamoto M, Yoneda N, Homma T, Higuchi Y, Sasaki E, Ogura A.   +11 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source