Results 41 to 50 of about 63,552 (337)

Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer

National Science Review, 2019
Cloning of macaque monkeys by somatic cell nucleus transfer (SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases.
Zhen Liu, Yijun Cai, Zhaodi Liao, Yuting Xu, Yan Wang, Zhanyang Wang, Xiaoyu Jiang, Yuzhuo Li, Yong Lu, Yanhong Nie, Xiaotong Zhang, Chunyang Li, Xinyan Bian, M. Poo, Hung-Chun Chang, Qiang Sun   +15 more
semanticscholar   +1 more source

Functional consequences of mitochondrial mismatch in reconstituted embryos and offspring

The Journal of Reproduction and Development, 2019
Animal cloning technology has been developed to produce progenies genetically identical to a given donor cell. However, in nuclear transfer protocols, the recipient oocytes contribute a heritable mitochondrial genomic (mtDNA) background to the progeny ...
Kumiko TAKEDA
doaj   +1 more source

Single cell‐derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer‐derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman’s syndrome

Cell Proliferation, 2019
Because primary mesenchymal progenitor cells (adult‐MPCs) have various functions that depend on the tissue origin and donor, de novo MPCs from human pluripotent stem cells (hPSCs) would be required in regenerative medicine.
Sung-Min Jun, Mira Park, Ji Yoon Lee, S. Jung, J. Lee, S. Shim, Haengseok Song, Dong Ryul Lee   +7 more
semanticscholar   +1 more source

Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer Embryos

Cellular Physiology and Biochemistry, 2018
Background/Aims: Aberrantly high levels of H3K4me3, caused by incomplete epigenetic reprogramming, likely cause a low efficiency of somatic cell nuclear transfer (SCNT).
Zhiren Zhang, Yanhui Zhai, Xiaoling Ma, Shenmin Zhang, X. An, Hao Yu, Ziyi Li   +6 more
semanticscholar   +1 more source

Interspecies Somatic Cell Nuclear Transfer: Advancements and Problems [PDF]

Cellular Reprogramming, 2013
Embryologists working with livestock species were the pioneers in the field of reprogramming by somatic cell nuclear transfer (SCNT). Without the "Dolly experiment," the field of cellular reprogramming would have been slow and induced plutipotent cells (iPSCs) would not have been conceived.
Lagutina, I., Fulka, H., LAZZARI, GIOVANNA, GALLI, CESARE   +3 more
openaire   +4 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes

Epigenetics & Chromatin, 2012
Background Nuclear reprogramming is potentially important as a route to cell replacement and drug discovery, but little is known about its mechanism. Nuclear transfer to eggs and oocytes attempts to identify the mechanism of this direct route towards ...
Jullien Jerome, Astrand Carolina, Szenker Emmanuelle, Garrett Nigel, Almouzni Genevieve, Gurdon John B   +5 more
doaj   +1 more source

Nuclear reprogramming by somatic cell nuclear transfer – the cattle story [PDF]

Reproduction in Domestic Ruminants, 2007
Somatic cell nuclear transfer (cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Nuclear transfer has potential applications in agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes ...
Xiangzhong Yang, F Xue, Shouquan Zhang, L Yang, Carol Lynn Curchoe, Xiuchun Cindy Tian, Chikara Kubota, Li-Ying Sung, Du F, Sadie L. Smith   +9 more
openaire   +3 more sources