Results 51 to 60 of about 63,552 (337)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Study on Chemicals for Post-activation in Porcine Somatic Cell Nuclear Transfer

Journal of Animal Reproduction and Biotechnology, 2016
Since the first success of animal cloning, somatic cell nuclear transfer presented various ideas in many research areas such as regenerative medicine. However, SCNT embryos has poor survival rate. Therefore, numerous researches carried out to enhance the
Kyuhong Min, Seungwon Na, Euncheol Lee, Ghangyong Kim, Youngkwang Yu, Pantu Kumar Roy, Xun Fang, MB Salih, Jongki Cho   +8 more
doaj   +1 more source

Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts. [PDF]

PLoS ONE, 2018
Recently we have demonstrated the possibility to replace histones with protamine, through the heterologous expression of human protamine 1 (hPrm1) gene in sheep fibroblasts.
Luca Palazzese, Marta Czernik, Domenico Iuso, Paola Toschi, Pasqualino Loi   +4 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review [PDF]

Frontiers of Agricultural Science and Engineering, 2014
Oocytes are unique cells with the inherent capability to reprogram nuclei. The reprogramming of the somatic nucleus from its original cellular state to a totipotent state is essential for term development after somatic cell nuclear transfer.
Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI
doaj   +1 more source

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Journal of Visualized Experiments, 2018
Somatic cell nuclear transfer (SCNT) provides a unique opportunity to directly produce a cloned animal from a donor cell, and it requires the use of skillful techniques.
Rika Azuma, Kei Miyamoto, Mami Oikawa, M. Yamada, M. Anzai   +4 more
semanticscholar   +1 more source

Human Somatic Cell Nuclear Transfer Using Adult Cells [PDF]

Cell Stem Cell, 2014
Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts. However, successful SCNT with human cells has proved challenging to achieve, and thus far has only been reported with fetal or infant somatic cells.
Vicken Sepilian, Nathan R. Treff, Erin A. Kimbrel, Dong Ryul Lee, Jeoung Eun Lee, Ralph E. Dittman, Yumie Lee, Sung Han Shim, Young Gie Chung, Seung Wook Hong, Young Ho Choi, Jin Hee Eum, Robert Lanza   +12 more
openaire   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Nature Communications, 2020
Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.
Kimiko Inoue, Narumi Ogonuki, Satoshi Kamimura, Hiroki Inoue, Shogo Matoba, Michiko Hirose, Arata Honda, Kento Miura, Masashi Hada, Ayumi Hasegawa, Naomi Watanabe, Yukiko Dodo, Keiji Mochida, Atsuo Ogura   +13 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source